Results 101 to 110 of about 1,419,473 (306)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Concept exploration on the design requirements and design scheme of laser shock processing equipment [PDF]

, 2013
In order to development the laser shock processing equipment, the technical features and process demand are analysis. The design requirements about laser shock processing equipment are discussed in detail by the methods of use case analysis and sequence ...
Deng HB(邓华波), Zou, Chao, Liu WJ(刘伟军)   +2 more
core  

A Novel AI-Based Visual Stimuli Generation Approach for Environment Concept Design. [PDF]

Comput Intell Neurosci, 2022
Duan Y, Zhang J.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Proposal for a Formal Definition of the Design Concept

, 2013
A clear and unambiguous definition of the design concept would be use- ful for developing a cumulative tradition for research on design. In this article we suggest a formal definition of the concept design and propose a conceptual model linking concepts ...
Wand, Yair, Ralph, Paul
core  

Water Desalination Using the Once-through Multi-Stage Flash Concept: Design and Modeling. [PDF]

Materials (Basel), 2022
Thabit Q, Nassour A, Nelles M.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Design and technology education and the concept of property

, 2008
Knobler (1971) notes that within society at least three communities are affected by intellectual property rights and these include; the stakeholders who produce and distribute the new knowledge such as Microsoft or Disney, individual generators of new ...
Molwane, Olefile Bethuel, Mwendapole, Chinandu   +1 more
core   +1 more source

Air Corridors: Concept, Design, Simulation, and Rules of Engagement. [PDF]

Sensors (Basel), 2021
Muna SI, Mukherjee S, Namuduri K, Compere M, Akbas MI, Molnár P, Subramanian R.   +6 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source