Concept, Design, and Early Prototyping of a Low-Cost, Minimally Invasive, Fully Implantable Left Ventricular Assist Device. [PDF]
Bioengineering (Basel), 2022 Pleșoianu FA +5 more
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Rotorcraft flight-propulsion control integration: An eclectic design concept [PDF]
The NASA Ames and Lewis Research Centers, in conjunction with the Army Research and Technology Laboratories, have initiated and partially completed a joint research program focused on improving the performance, maneuverability, and operating ...
Ballin, Mark G. +2 more
core +1 more source
Heinz Isler: shells for two churches [PDF]
, 2011 This paper describes the concept, design and realisation of two churches where Heinz Isler (1926-2009) was responsible for the structural design and in one case also for the architectural concept. One example, the Heilig Geist Kirche (Holy Spirit Church)
Chilton, JC
core
Concept design of the physical structure for ICU ventilators for COVID-19 pandemic. [PDF]
Sens Int, 2021 Agarwal KM +3 more
europepmc +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An Integrated Decision Making Model for Evaluation of Concept Design
Acta Polytechnica, 2004 The Conceptual design phase generates various design concepts and these are then evaluated in order to identify the 'Best’ concept. Identifying the Best concept is important because much of the product life cycle cost is decided in this phase.
G. Green, G. Mamtani
doaj
Human centred manufacturing: methodology for ergonomic previsional evaluation of manual assembly operations [PDF]
, 2013 The challenge of flexibility and productivity for manufacturing operations needs a new concept based on “human-centered manufacturing process”. This concept must consider basically the ergonomics of workplaces and workload balancing.
Costantino, Marco +3 more
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Experimental combustor study program [PDF]
, 1980 Advanced combustor concepts are evaluated as a means of accommodating possible future broad specification fuels. The three advanced double annular combustor concepts consisted of (1) a concept employing high pressure drop fuel nozzles for improved ...
Ekstedt, E. E., Kasper, J. M.
core +1 more source