Results 71 to 80 of about 1,419,473 (306)

The Mute Aisling: Staging Sociopolitical Shifts through Disability in the Abbey Theatre’s Productions of Translations

open access: yes, 2019
In a play of divided lands and language, Sarah John Sally in Brian Friel’s Translations presents a unique bifurcation; somewhere between character and caricature, aisling and invalid, the actor performing Sarah must tread a delicate balance between ...

core  

Concept of Spaceborne Ocean Microwave Dual-Function Integrated Sensor for Wind and Wave Measurement

open access: yesRemote Sensing
Dedicated to synchronously acquiring large-area, high-precision, and multi-scale ocean wind and wave information, a novel concept of a spaceborne ocean microwave dual-function integrated sensor is proposed in this paper.
Hang Li   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An investigation into the concept of motivation within design

open access: yes, 2011
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.This thesis argues that there is a need for design practitioners and design researchers to more clearly articulate and understand the role of design in ...
Bisset, Fergus
core  

TRIZ Evolution Trends in Biological and Technological Design Strategies [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityThe concept of evolution in technology and biology is discussed. It appears that most of the evolution trends in technology and biology result from different development strategies.
Bogatyrev, N. R., Bogatyreva, O. A.
core  

Concept models for design practice

open access: yesBitácora Urbano Territorial, 2017
Concept models are common guides to living, and some more specialized ones, which have been developed and validated in other fields have been adopted by designers for use in their work. In particular, concept models serve as templates for decision-making
Stan Ruecker
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Effects of computer-supported collaboration script and incomplete concept maps on web design skills in an online design-based learning environment [PDF]

open access: yes, 2012
Web design skills are an important component of media literacy. The aim of our study was to promote university students’ web design skills through online design-based learning (DBL).
El-Refai, Walid
core  

Overcoming Design Fixation in Idea Generation

open access: yes, 2018
Ideally, designers move past existing ideas to create novel designs. But designers often experience “fixation,” where new ideas are similar to existing designs.
Seifert, Colleen   +7 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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