Results 111 to 120 of about 5,397,718 (323)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Combining instance selection and self-training to improve data stream quantification

Journal of the Brazilian Computer Society, 2018
In the last years, learning from data streams has attracted the attention of researchers and practitioners due to its large number of applications. These applications have motivated the research community to propose a significant amount of methods to ...
André G. Maletzke, Denis M. dos Reis, Gustavo E. A. P. A. Batista   +2 more
doaj   +1 more source

Mining Massive E-Health Data Streams for IoMT Enabled Healthcare Systems

Sensors, 2020
With the increasing popularity of the Internet-of-Medical-Things (IoMT) and smart devices, huge volumes of data streams have been generated. This study aims to address the concept drift, which is a major challenge in the processing of voluminous data ...
Affan Ahmed Toor, Muhammad Usman, Farah Younas, Alvis Cheuk M. Fong, Sajid Ali Khan, Simon Fong   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fast Learning and Testing for Imbalanced Multi-Class Changes in Streaming Data by Dynamic Multi-Stratum Network

IEEE Access, 2017
Although several efficient learning methods have recently been proposed to handle class drift situations, issues remain in various streaming data applications that possibly deteriorate classification accuracy. Three important issues were considered, that
Mongkhon Thakong, Suphakant Phimoltares, Saichon Jaiyen, Chidchanok Lursinsap   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Comparison of Approaches for Handling Concept Drifts in Data Processed With Machine Learning

IEEE Access
In the realm of machine learning models, the pursuit of achieving favorable metrics is undeniably significant. However, these models confront phenomena that can diminish their effectiveness if left unaddressed-notably, the phenomenon of concept drift ...
Emanuel Valerio Pereira, Wendley Souza da Silva   +1 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Organic Farming Certification – the Costs of Reducing Transaction Costs [PDF]

, 2008
Since 1991, the European Union regulates the organic food market. By implementing the organic regulation and the corresponding inspection and certification system, organic markets were fostered, but the financial costs and bureaucratic drift of this ...
Zorn, Alexander
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