Results 191 to 200 of about 12,875 (244)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

In their own words: experiences surrounding masculinising chest surgery among transgender and gender-diverse adolescents - a secondary analysis of GENDER-Q data. [PDF]

BMJ Open
Armstrong K, Quan I, Kennedy SL, Kaur MN, Cornacchi SD, Rae C, Johnson N, Khatchadourian K, Marinkovic M, Sequeira GM, Bradley B, Cheung K, Morrison SD, Klassen AF.   +13 more
europepmc   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Development of the Sinus Headache Screener to identify patients with non-rhinogenic facial pain compared with chronic rhinosinusitis in rhinology clinics. [PDF]

J Patient Rep Outcomes
Coles T, Mkumba LS, Wright L, Godley FA, Collins TA, Jang DW.   +5 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

A framework for the recursive risk-ranking of foodborne zoonotic threats along food supply chains. [PDF]

One Health
Al Dahouk S, Montibeller G.
europepmc   +1 more source

What Is Important to Patients? A Mixed Methods Study to Understand Patient Experience Commonalities Across Three Conditions. [PDF]

Patient
Majercak KR, Perfetto EM, Mullins CD.
europepmc   +1 more source

The PKD Daily: Development and Content Validation of a Hybrid Diary for Tracking Urinary Events in Adults with Autosomal Dominant Polycystic Kidney Disease (ADPKD). [PDF]

Adv Ther
O'Connor M, Broderick L, Waldman LT, Costa E, Carty M, Nunna S, Oberdhan D.   +6 more
europepmc   +1 more source

Bayesian prior elicitation on the efficacy of medical therapies in perianal fistulizing Crohn's disease. [PDF]

J Crohns Colitis
Noor NM, Zheng H, Cao Z, Caruso G, Voller C, Cooney R, Din S, Gordon H, Kok KB, Lindsay JO, Moran GW, Patel KV, Sebastian S, Raine T, Subramanian S, Hart AL, Robertson DS, Parkes M.   +17 more
europepmc   +1 more source

Creation of the First Comparative Gluten Allergenicity Map Using a Mouse Model: A Preclinical Tool to Establish Substantial Equivalence of Novel Wheat Glutens. [PDF]

Int J Mol Sci
Jorgensen R, Gao H, Acharya HG, Srkalovic MB, Van Antwerp C, Ng PKW, Gangur V.   +6 more
europepmc   +1 more source