Results 81 to 90 of about 95,304 (285)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
The ZMET Technique: A New Paradigm for Improving Marketing and Marketing Research [PDF]
, 2005 For decades, marketing and marketing research have been based on a concept of consumer behaviour that is deeply embedded in a linear notion of marketing activities.
van Dessel, Maria
core +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Collaborative mint map tool to facilitate requirement elicitation [PDF]
, 2011 Requirements elicitation is a crucial task in any software development process.It is notable as a major contributor to the project failure.To minimize and subsequently improve the process, folding Mind Map concept in the elicitation process and ...
Abdul Hamid, Nazatul Naquiah Ahba +2 more
core
Communication issues in requirements elicitation: A content analysis of stakeholder experiences [PDF]
, 2003 The gathering of stakeholder requirements comprises an early, but continuous and highly critical stage in system development. This phase in development is subject to a large degree of error, influenced by key factors rooted in communication problems ...
Al-Rawas +54 more
core +2 more sources
Using Videos to Elicit Self-Explanations of Emergent Electromagnetic Concepts [PDF]
2016 ASEE Annual Conference & Exposition Proceedings, 2016 It is well documented that students have more difficulty comprehending and mastering emergent schemas in comparison to direct-causal schemas or concepts. Compared to some other disciplines, electrical engineering tends to have many emergent concepts, particularly in electromagnetics where most phenomena are not directly observable by humans and many ...
Alan Cheville, Brianna Healey Derr
openaire +2 more sources
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Capturing Emotional Concepts During Concept Elicitation [PDF]
Value in Health, 2015 Forbes, D, Saunders, D, Cole, JC
openaire +2 more sources
Measuring Risk Aversion Model-Independently [PDF]
, 2010 We propose a new method to elicit individuals' risk preferences. Similar to Holt and Laury (2002), we use a simple multiple price-list format. However, our method is based on a general notion of increasing risk, which allows classifying individuals as ...
Maier, Johannes, Rüger, Maximilian
core +2 more sources