Results 61 to 70 of about 95,304 (285)

Eliciting patient-important outcomes through group brainstorming: when is saturation reached?

Journal of Patient-Reported Outcomes, 2019
Purpose Group brainstorming is a technique for the elicitation of patient input that has many potential uses, however no data demonstrate concept saturation. In this study we explore concept saturation in group brainstorming performed in a single session
Marianna LaNoue, Alexzandra Gentsch, Amy Cunningham, Geoffrey Mills, Amanda M. B. Doty, Judd E. Hollander, Brendan G. Carr, Larry Loebell, Gail Weingarten, Kristin L. Rising   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Protocol for the development of a patient-reported outcome measure for patients with hypospadias

BMJ Open
Introduction Existing patient-reported outcome measures (PROMs) do not meet accepted international criteria for measuring health outcomes of hypospadias treatment.
Anne Klassen, Erin McNamara, Elena Tsangaris, Melise A Keays, Sonia Gulati, Christopher Long, Luis H Braga   +6 more
doaj   +1 more source

Mapping IranDoc Brand Associations Network from the Stakeholders’ Viewpoint

Iranian Journal of Information Processing & Management, 2021
The dominance of pragmatic paradigm in science and technology policy has changed the approach to the management of scientific institutes. In pragmatic paradigm, scientific institutes should be able to respond stakeholders’ needs and requirements.
Somayeh Labafi,
doaj  

Development of a Conceptual Model of the Patient Experience in Small Cell Lung Cancer: A Qualitative Interview Study

Oncology and Therapy, 2023
Introduction Small cell lung cancer (SCLC) is a subtype of lung cancer, the second most common cancer diagnosis worldwide. Currently, there is little published qualitative research that provides insight into the disease-related symptoms and impacts that ...
Danielle E. Altman, Xinke Zhang, An-Chen Fu, Alissa R. Rams, Jessica A. Baldasaro, Samir Ali Ahmad, Michael Schlichting, Patrick Marquis, Elena Benincasa, Camilo Moulin, Vivek Pawar   +10 more
doaj   +1 more source

Investigating the concept of representation in the neural and psychological sciences

Frontiers in Psychology, 2023
The concept of representation is commonly treated as indispensable to research on brains, behavior, and cognition. Nevertheless, systematic evidence about the ways the concept is applied remains scarce.
Luis H. Favela, Luis H. Favela, Edouard Machery, Edouard Machery, Edouard Machery   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Discourse through making: eliciting knowledge to support craft skills learning [PDF]

, 2007
In this paper I describe the development of techniques for eliciting craft knowledge for use in an interactive learning resource, illustrated with examples from two practical research projects.
Wood, N.
core  

Comment: Expert Elicitation for Reliable System Design

, 2007
Comment: Expert Elicitation for Reliable System Design [arXiv:0708.0279]Comment: Published at http://dx.doi.org/10.1214/088342306000000547 in the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.
Wang, Wenbin
core   +1 more source