Results 41 to 50 of about 3,513,756 (283)

Developing an Edema Clinician-Reported Outcome Measure for Nephrotic Syndrome

Glomerular Diseases, 2023
Introduction: Edema is a common manifestation of proteinuric kidney diseases but there is no consensus approach for reliably evaluating edema. The objective of this study was to develop an edema clinician-reported outcome measure for use in patients with
Debbie S. Gipson, Maisha Pal, Hailey Desmond, Charles Anderson, Liron Walsh, Howard Trachtman, Susan F. Massengill, Patrick Gipson, Panduranga S. Rao, Joshua Thurman, Jeffrey Kopp, Elaine Kamil, Jennifer Lamothe, Laura H Mariani, Paula LaFleur, Suzanne Vento, Michelle O’Shaughnessy, Youssef M.K. Farag, Christine Simon, Noelle E. Carlozzi   +19 more
doaj   +1 more source

Intermediary's Elicitation and Patron's Retrieval Satisfaction [PDF]

, 2010
[[abstract]]An elicitation is a verbal request for information reflecting one's interests, concerns or perplexities in conversation. Elicitation behavior in studies of information retrieval interaction is, in fact, the micro-level of information-seeking ...
Wu, Mei-Mei;Liu, Ying-Hasng;Chiang, Hsing-Jung, 吳美美; 姜杏蓉; 劉英享, Wu, Mei-Mei; Chiang, Hsing-Jung; Liu, Ying-Hsang, 吳美美;劉英享;姜杏蓉   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Eliciting patient-important outcomes through group brainstorming: when is saturation reached?

Journal of Patient-Reported Outcomes, 2019
Purpose Group brainstorming is a technique for the elicitation of patient input that has many potential uses, however no data demonstrate concept saturation. In this study we explore concept saturation in group brainstorming performed in a single session
Marianna LaNoue, Alexzandra Gentsch, Amy Cunningham, Geoffrey Mills, Amanda M. B. Doty, Judd E. Hollander, Brendan G. Carr, Larry Loebell, Gail Weingarten, Kristin L. Rising   +9 more
doaj   +1 more source

The use of photo-elicitation interviewing in qualitative HRD research [PDF]

, 2015
The chapter provides an overview of the as yet under- utilised tool of photo-elicitation interviewing. It examines the development of this method and its value to HRD research.
Black, Kate, Warhurst, Russell
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Protocol for the development of a patient-reported outcome measure for patients with hypospadias

BMJ Open
Introduction Existing patient-reported outcome measures (PROMs) do not meet accepted international criteria for measuring health outcomes of hypospadias treatment.
Anne Klassen, Erin McNamara, Elena Tsangaris, Melise A Keays, Sonia Gulati, Christopher Long, Luis H Braga   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Mapping IranDoc Brand Associations Network from the Stakeholders’ Viewpoint

Iranian Journal of Information Processing & Management, 2021
The dominance of pragmatic paradigm in science and technology policy has changed the approach to the management of scientific institutes. In pragmatic paradigm, scientific institutes should be able to respond stakeholders’ needs and requirements.
Somayeh Labafi,
doaj