Results 91 to 100 of about 2,843,609 (294)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nursing diagnosis proposal "Impaired Peripheral Venous Return": concept formation. [PDF]
Rev Bras Enferm, 2023 Medeiros HPDS +5 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
EngThis study presents the design, development, and evaluation of a multifunctional stepladder that integrates four functionalities: a stepladder, Pilates chair, wheelchair, and walking aid. Unlike existing research that focuses on single-function assistive
Elwin Nesan Selvanesan +6 more
doaj +1 more source
SERKET: An Architecture for Connecting Stochastic Models to Realize a Large-Scale Cognitive Model
Frontiers in Neurorobotics, 2018 To realize human-like robot intelligence, a large-scale cognitive architecture is required for robots to understand their environment through a variety of sensors with which they are equipped. In this paper, we propose a novel framework named Serket that
Tomoaki Nakamura +2 more
doaj +1 more source
Concept formation as a computational cognitive process. [PDF]
Curr Opin Behav Sci, 2021 Morton NW, Preston AR.
europepmc +1 more source
A Distributed Merge and Split Algorithm for Fair Cooperation in Wireless Networks
, 2008 This paper introduces a novel concept from coalitional game theory which allows the dynamic formation of coalitions among wireless nodes. A simple and distributed merge and split algorithm for coalition formation is constructed. This algorithm is applied
Debbah, Merouane +3 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Cooperation-based concept formation in male bottlenose dolphins. [PDF]
Nat Commun, 2021 King SL +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source