Results 71 to 80 of about 544,256 (319)

Desenvolvimento de conceitos em cegos congênitos: caminhos de aquisição do conhecimento

Psicologia Escolar e Educacional
O objetivo deste trabalho foi estudar o desenvolvimento de conceitos por cegos congênitos. Participaram sete cegos congênitos, de ambos os sexos, com idades entre 8 e 13 anos.
Sylvia da Silveira Nunes, José Fernando Bitencourt Lomônaco   +1 more
doaj  

Design and Development of a Multifunctional Stepladder: Usability, Sustainability, and Cost-Effectiveness

Eng
This study presents the design, development, and evaluation of a multifunctional stepladder that integrates four functionalities: a stepladder, Pilates chair, wheelchair, and walking aid. Unlike existing research that focuses on single-function assistive
Elwin Nesan Selvanesan, Poh Kiat Ng, Kia Wai Liew, Kah Wei Gan, Peng Lean Chong, Jian Ai Yeow, Yu Jin Ng   +6 more
doaj   +1 more source

Kick-starting concept formation with intrinsically motivated learning: the grounding by competence acquisition hypothesis. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Mannella F, Tummolini L.
europepmc   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Concept formation as a computational cognitive process. [PDF]

Curr Opin Behav Sci, 2021
Morton NW, Preston AR.
europepmc   +1 more source

CELLULAR REACTIONS TO A DYE-PROTEIN WITH A CONCEPT OF THE MECHANISM OF ANTIBODY FORMATION [PDF]

, 1939
Florence Sabin
openalex   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Cooperation-based concept formation in male bottlenose dolphins. [PDF]

Nat Commun, 2021
King SL, King SL, Connor RC, Krützen M, Allen SJ.   +4 more
europepmc   +1 more source

Schematic concept formation: Demonstration in a free sorting task [PDF]

, 1967
Selby H. Evans, Malcolm D. Arnoult
openalex   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source