The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Enhancement of Inferring Skill and Concept Mastery in Basic Thermochemistry Subject by Learning Cycle 5e Model [PDF]
This research is intended to describe the effective characteristics of learning cycle 5E (LC 5E) teaching method in increasing students’ inferring skill and concept mastery in basic termokimia subject of SMA Negeri 6 Bandar Lampung. The samples of ...
diawati, C. (chansyanah) +2 more
core
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The purpose of this study was to determine the effect of KWL strategy on students' mastery of the material concept of ecosystems. The hypothesis of this study is the use of learning strategies KWL on ecosystem material and significant positive effect on ...
Nia Kurniasih, Milla Listiawati
doaj +1 more source
Pengaruh Penggunaan Laboratorium Virtual Terhadap Penguasaan Konsep Dan Kemampuan Berpikir Kreatif Siswa Pada Materi Getaran Dan Gelombang [PDF]
This research aims to know the effect of using virtual laboratorial towards concept mastery and creative thinking ability of students on the material of vibrations and waves.
Gunawan, G. (Gunawan) +2 more
core
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Penerapan Model Pembelajaran Inkuiri Abduktif untuk Meningkatkan Keterampilan Berpikir Kritis dan Penguasaan Konsep Siswa pada Materi Dinamika [PDF]
The aims of this study to determine the increase in critical thinking skills and mastery of the concept after the application of abductive inquiry learning model at high school students.
Ramalis, T. R. (Taufik) +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ANALISIS KEMAMPUAN PENALARAN DAN PENGUASAAN KONSEP SISWA PADA SISTEM INDERA MELALUI MODEL PEMBELAJARAN GUIDED INQUIRY [PDF]
Penelitian ini bertujuan untuk menganalisis kemampuan penalaran dan penguasaan konsep siswa SMA pada konsep sistem indera melalui model pembelajaran Guided Inquiry.
Syahida, Ida
core
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source

