Results 121 to 130 of about 562,483 (308)

The nature of culture : an eight-grade model for the evolution and expansion of cultural capacities in hominins and other animals

, 2015
Tracing the evolution of human culture through time is arguably one of the most controversial and complex scholarly endeavors, and a broad evolutionary analysis of how symbolic, linguistic, and cultural capacities emerged and developed in our species is ...
Collard, Mark, Haidle, Miriam Noël, Conard, N., Tennie, Claudio, Bolus, M., Whiten, A., Haidle, M.N., Nowell, April, Haidle, M., Nowell, A., Lombard, Marlize, Haidle, Miriam, Tennie, C., Collard, M., Tennie, C. ; https://orcid.org/, Bolus, Michael, Whiten, Andrew, Garofoli, D., Garafoli, Duilio, Garofoli, Duilio, Conard, N.J., Conard, Nicholas, Lombard, M.   +22 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Concept of Culture [PDF]

Nature, 1950
openaire   +2 more sources

Special Review Article: Beyond Culture or Beyond Control? Reviewing the use of Hall's high-/low-context concept

, 2011
This paper reviews Edward T. Hall’s influential concept of high-/low-context communication and its use in cross-cultural research. Hall’s concept suggests that individuals combine preprogrammed culture specific context and information to create meaning ...
Mackinnon, Alex, Kittler, Markus, Markus G. Kittler, Kittler, Markus G., Alex Mackinnon, Rygl, David, David Rygl   +6 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Behavioral Equivalence of Organizational Culture [PDF]

Three decades of organizational cultural (OC) studies have seen change in both content and emphasis. This paper presents findings from an extensive review of literature on OC and highlights the relevance of OC with respect to individual, organizational ...
Rao Indu
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Using the concept of legal culture [PDF]

, 2004
Discusses the problems with the concept of legal culture and offers the challenge of explaining italian court delays as a case study of the difficulties and benefits of using the ...
NELKEN, David
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Conception de l'histoire, concept de culture européenne chez Jean Améry et Imre Kertész

Études romanes de Brno, 2013
In the 20th century the European literature had to face the difficulties of History's representation. Its most evident example is the Shoah: although the genre of novel always has kept a critical attitude towards the traditions of the European philosophy
Dorottya Szávai
doaj