Results 131 to 140 of about 562,483 (308)
The political career of the culture concept
, 2018 My concerns in this chapter are with the discursive coordinates that shaped a distinctive episode in the political career of the cultural concept: that comprised by the role it played in the development of assimilationist conceptions of multiculturalism
Bennett, Tony (R15087)
core
Constructing the concept of 'culture' in a Mexican university language department: the struggles of a small group of English teachers and students [PDF]
, 2013 This thesis is an investigation of how a group of foreign and local English language teachers and students at the Language Department of the University of Guanajuato, Mexico construct ‘culture’.
Armenta Delgado, I.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Tom’s European Fantasies: Commodifying Authenticity in The Talented Mr. Ripley
Patricia Highsmith’s The Talented Mr. Ripley (1955) allegorizes the American project of restructuring postwar Europe into its mirror image. In this study, Tom Ripley, Highsmith’s famed sociopathic impersonator, is read as a personified simulacrum of ...
Parker, Jaxon
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Debate: The concept of culture has outlived its usefulness for psychiatry. [PDF]
BJPsych Bull, 2018 Rashed MA +4 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Mary Magdalene: Sexism and Feminism in Scorsese\u27s "The Last Temptation of Christ"
The following paper centers on the figure of Mary Magdalene in the movie The Last Temptation of Christ (1988), interpreted by actress Barbara Hershey and directed by Martin Scorsese.
Lopez-Egea I Vives, Angela
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source