Results 81 to 90 of about 2,853,998 (305)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Liang Shuming’s Concept of Culture: The Chinese Way

Концепт: философия, религия, культура
The article is devoted to the analysis of the discussions around the theory of cultural interactions by Chinese philosopher Liang Shuming. The teaching was formed in the 1920s in the framework of New Culture Movement and resonated both with ...
Gao Qing, M. N. Fomina
doaj   +1 more source

Development Of Metacognitive And Discursive Activities In Indonesian Maths Teaching A theory based analysis of communication processes [PDF]

, 2011
We report on a German-Indonesian feasibility study which aims to significantly increase the mathematical skills of Indonesian secondary school students.
Christa , Kaune, Edyta , Nowinska
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Encyclopedia of Tuvan culture: timeliness, concept, problems

Новые исследования Тувы, 2016
Article arises the problem of creating the encyclopedia of Tuvan culture. History of development of encyclopedia projects in world culture is reviews as well as description of the variants of encyclopedias in 20th century. Characteristics of dictionaries
Chimiza K. Lamazhaa
doaj  

Scientific Instruments and Epistemology Engines [PDF]

, 2012
This article outlines the gradually changing attitude towards instruments and materials in the philosophy and historiography of science and confronts contemporary revaluations of the material culture of science with Hans-Jörg Rhein- berger's concept of ...
Dvořák, Tomáš
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Continuity in the Concept: A Concept Analysis of Quality Culture in Complex Adaptive Systems

Vietnam Journal of Education, 2023
In this article we define the concept of quality culture in a complex higher education context. The article aims to start a creative dialogue on the conceptual continuity of the concept of quality culture in the form of a literature review.
Everard van Kemenade
doaj  

Pleasure and meaningful discourse: an overview of research issues [PDF]

, 2000
The concept of pleasure has emerged as a multi-faceted social and cultural phenomenon in studies of media audiences since the 1980s. In these studies different forms of pleasure have been identified as explaining audience activity and commitment.
Abercrombie, Nicholas, Alasuutari, Pertti, Ang, Ien, Barbara O’Connor, Barthes, Roland, Benhabib, Seyla, Brown, Mary Ellen, Brunsdon, Charlotte, Chodorow, Nancy, Connor, Steven, Corner, John, Corner, John, Corrigan, Philip, Dahlgren, Peter, Dyer, Richard, Dyer, Richard, Elisabeth Klaus, Fiske, John, Fiske, John, Fiske, John, Fiske, John, Fraser, Nancy, Frith, Simon, Gallagher, Margaret, Geraghty, Christine, Geraghty, Christine, Grossberg, Lawrence, Hall, Stuart, Hamm, Ingrid, Hermes, Joke, Hermes, Joke, Hobson, Dorothy, Jameson, Frederic, Koch, Tom, Langer, John, Langer, John, Lefebvre, Henri, Lewis, Justin, Livingstone, Sonia M., Livingstone, Sonia M., Lovell, Terry, Mercer, Colin, Modleski, Tania, Morley, David, Morley, David, Morley, David, Morley, David, Nightingale, Virginia, Nochimson, Martha, O’Connor, Barbara, Penley, Constance, Radway, Janice A., Schmitz, Manfred, Seiter, Ellen, Van Zoonen, Liesbet, Williams, Raymond   +55 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source