Results 61 to 70 of about 2,853,998 (305)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Un breve itinerario storico-filosofico intorno al concetto di cultura [PDF]

open access: yesDemocrazia e Diritti Sociali
The essay outlines a brief itinerary around the different meanings of the concept of culture, made even more difficult to understand because, due to process of homogenisation, it is increasingly complex to establish a shared notion of culture.
Maurizio Martirano
doaj  

The Concept of Political Culture in Polish Empirical Research

open access: yesTeoria Polityki
The text concerns empirical research on political culture in Poland. A synthetic outline of the most important findings concerning the definitions of political culture is followed by a presentation of
Joanna Dzwończyk
doaj   +1 more source

THE CONCEPT OF TAX CULTURE IN CONTEMPORARY TIMES

open access: yesIustinianus Primus Law Review, 2023
In the last few years countries have been struggling to meet their objectives of protecting  common goods and providing public services. The race – to the-bottom approach, accompanied with narrow tax bases, low tax rates and number of tax incentives ...
Elena Neshovska Kjoseva
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Seishin Habitus: Spiritual Capital and Japanese Rowing [PDF]

open access: yes, 1995
Sport occupies an important place in educational curriculum, such as club activities in Japanese schools and universities; is it also imbued with what Bourdieu suggests are guaranteed capital properties?
Erba, Elisabetta   +2 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Littleness of the Culture in the Middle Europe for Example Slovensko a jeho život literárny (Slovakia and Her Literary Life) by Jozef Miloslav Hurban ). [PDF]

open access: yesSlovenska Literatura, 2005
“Littleness” appears as relevant for certain culture when it is determined by its own or foreign texts. This determination in an intercultural contact behaves as an explicit or implicit valuing act approached within the positions of superiority ...
CHRISTIAN PRUNITSCH
doaj  

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