Results 121 to 130 of about 411,891 (262)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Violence Management in Mental Health Nursing: A Conceptual Analysis. [PDF]

Int J Ment Health Nurs
Takahashi K, Tanaka K, Nagata K.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Overvalued Ideas: Conceptual Analysis and Literature Review. [PDF]

Behav Sci (Basel)
Dork J, Dimenstein E, Burns L, Demshuk M.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Intertemporal Decision-Making in Health Behaviours: A Conceptual Analysis. [PDF]

J Nurs Manag
Fan S, Lai X, Ma J, Zhu Y, Xiao X, Zhou Y, Wang H.   +6 more
europepmc   +1 more source

Elder abuse: a conceptual analysis. [PDF]

Rev Bras Enferm, 2023
Santos-Rodrigues RCD, Araújo-Monteiro GKN, Dantas AMN, Beserra PJF, Morais RM, Souto RQ.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of structure of self⁃management concepts in patients with gastrointestinal cancer during chemotherapy

Huli yanjiu, 2022
ZHENG Su'na, PENG Jian, XING Weijie, ZHANG Xiaoju, YANG Yang, HU Yan   +5 more
doaj  

Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model. [PDF]

Psychophysiology
Evstigneev SR, Wilhelm FH, Slavich GM, Blum D, Seiler A.   +4 more
europepmc   +1 more source