Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A conceptual analysis of reflective supervision for creating a positive intensive care practice environment. [PDF]
Int J Nurs SciChipu MG.
europepmc +1 more source
A Conceptual Analysis of Mental Health Maladaptation in Postpartum. [PDF]
J Perinat Educ, 2023 DeFoor M, Amiri A.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
From scarcity to ultra-processed foods: a conceptual analysis of how their properties interact with characteristics of food intake regulation mechanism. [PDF]
Front NutrOosterlinck F, Segers Y.
europepmc +1 more source
Pathologizing Ugliness: A Conceptual Analysis of the Naturalist and Normativist Claims in "Aesthetic Pathology". [PDF]
J Med Philos, 2022 Aquino YSJ.
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Adopting telehealth for mental health support in stroke rehabilitation in Sub-Saharan Africa: A conceptual analysis using Rogers' Diffusion of Innovation Theory. [PDF]
PLOS Glob Public HealthTsogbe D, Martin T, Bernice Gyanmea A.
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Job Crafting in Nursing: A Conceptual Analysis for Theoretical Advancements in Nursing Practice. [PDF]
J Nurs ManagYuan X, Yin X, Zhang X, Ju Z.
europepmc +1 more source