Results 161 to 170 of about 2,244,720 (326)

Block 2 SRM conceptual design studies. Volume 1, Book 1: Conceptual design package [PDF]

The conceptual design studies of a Block 2 Solid Rocket Motor (SRM) require the elimination of asbestos-filled insulation and was open to alternate designs, such as case changes, different propellants, modified burn rate - to improve reliability and ...
Doll, Dan, Hayes, Fred, Maughan, Jeff, Miller, John, Moore, Walt, Ralston, Joe, Richardson, Jennifer, Smith, Brad, Williams, Neal   +8 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Design in the natural stone transformation sector: evaluating a new concept

Ingeniería e Investigación, 2012
The European natural stone sector is declining; sales and imports are decreasing, owing to growing competition from Asiatic countries concerning the diversity of low-cost materials and European cultural and historical traditions demanding a commitment to
Susana Paixão-Barradas, Bernabé Hernandis Ortuño, Begoña Agudo Vicente, Isadora Dickie, Karla Mazarelo Maciel Pacheco   +4 more
doaj  

ARGONNE HIGH-FLUX RESEARCH REACTOR-AHFR CONCEPTUAL DESIGN STUDY

, 1959
Lewis E. Link, Robert H. Armstrong, T.C. Cameron, J.B. Heineman, C.N. Kelber, P.H. Kier, Harry F. Iii Reed, R.R. Rohde, A.D. Rossin, Washat Ware   +9 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A semantic analysis-driven customer requirements mining method for product conceptual design. [PDF]

Sci Rep, 2022
Wu XY, Hong ZX, Feng YX, Li MD, Lou SH, Tan JR.   +5 more
europepmc   +1 more source

Experiences performing conceptual design optimization of transport aircraft [PDF]

Optimum Preliminary Design of Transports (OPDOT) is a computer program developed at NASA Langley Research Center for evaluating the impact of new technologies upon transport aircraft.
Arbuckle, P. D., Sliwa, S. M.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

To Whom Belongs Conceptual Design?

Acta Polytechnica, 2003
The field of Conceptual Design is very alive and is rapidly developing. This paper investigates the disciplines and domains which substantially form its profile.
J. Bíla
doaj  

Conceptual Design of a Portable, Solid-Nitrogen-Cooled 0.5-T/560-mm Point-of-Care MRI Magnet. [PDF]

IEEE Trans Appl Supercond, 2023
Park D, Bascuñán J, Lee W, Iwasa Y.
europepmc   +1 more source