Results 141 to 150 of about 329,719 (257)

Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities. [PDF]

Chembiochem
Yoshimura M, Inose T.
europepmc   +1 more source

CDFA method: a way to assess assembly and installation performance of aircraft system architectures at the conceptual design. [PDF]

Res Eng Des, 2022
Formentini G, Bouissiere F, Cuiller C, Dereux PE, Favi C.   +4 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications. [PDF]

Acta Pharm Sin B
Yin Y, Zhao Q, Wang Z, Li Z, Liu H, Eghbalitabar F, Shang J, Tang L, Wang W.   +8 more
europepmc   +1 more source

Review on the Conceptual Design of Self-Healable Nitrile Rubber Composites. [PDF]

ACS Omega, 2021
Roy K, Debnath SC, Pongwisuthiruchte A, Potiyaraj P.   +3 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Zhuque Base for Martian Habitation: Conceptual Design and Performance Analysis of Cave Dwellings and In Situ Construction. [PDF]

Research (Wash D C)
Zhou C, Cheng S, Gao Y, Zhao J, Xiao L, Ding L.   +5 more
europepmc   +1 more source

Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams. [PDF]

Cancers (Basel), 2021
Schneider T, Patriarca A, Degiovanni A, Gallas M, Prezado Y.   +4 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Conceptual Design of a Hybrid Composite to Metal Joint for Naval Vessels Applications. [PDF]

Materials (Basel)
Cheung MC, Djordjevic N, Worrall C, Vignjevic R, Kazilas M, Hughes K.   +5 more
europepmc   +1 more source