Results 161 to 170 of about 2,272,322 (296)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A Conceptual Design of Smart Management System for Flooding Disaster. [PDF]

Int J Environ Res Public Health, 2021
Ibrahim T, Mishra A.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Radiation Hardened LIDAR Sensor: Conceptual Design, Testing, and Performance Evaluation. [PDF]

Sensors (Basel)
Jonasson ET, Kuhlmann C, Wood C, Skilton R.   +3 more
europepmc   +1 more source

Conceptual Design and Prototyping for a Primate Health History Knowledge Model. [PDF]

Adv Comput Vis Comput Biol (2020), 2021
Zhao MQ, Maldonado E, Kensler TB, Kohn LAP, Guatelli-Steinberg D, Wang Q.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The Conceptual Design of a Variable Camber Wing. [PDF]

Biomimetics (Basel)
Cortez STP, Winyangkul S, Sleesongsom S.
europepmc   +1 more source

CDFA method: a way to assess assembly and installation performance of aircraft system architectures at the conceptual design. [PDF]

Res Eng Des, 2022
Formentini G, Bouissiere F, Cuiller C, Dereux PE, Favi C.   +4 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities. [PDF]

Chembiochem
Yoshimura M, Inose T.
europepmc   +1 more source