Results 131 to 140 of about 329,719 (257)

Conceptual Design of a Portable, Solid-Nitrogen-Cooled 0.5-T/560-mm Point-of-Care MRI Magnet. [PDF]

IEEE Trans Appl Supercond, 2023
Park D, Bascuñán J, Lee W, Iwasa Y.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Conceptual Design and Electromagnetic-Thermal Coupling Analysis of Superconducting Current-Limiting Reactor Under Self-Triggered Built-In Magnetic Field Excitation. [PDF]

Materials (Basel)
Yu Q, Xu H, Chen X, Wang B, Zhao H, Yang J, Xu Q, Qing K.   +7 more
europepmc   +1 more source

V-CarE-A Conceptual Design Model for Providing COVID-19 Pandemic Awareness: Proposal for a Virtual Reality Design Approach to Facilitate People With Persistent Postural-Perceptual Dizziness. [PDF]

JMIR Res Protoc, 2023
Zaidi SFM, Shafiabady N, Afifi S, Beilby J.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Conceptual Design of a Variable Camber Wing. [PDF]

Biomimetics (Basel)
Cortez STP, Winyangkul S, Sleesongsom S.
europepmc   +1 more source

Conceptual Design and Prototyping for a Primate Health History Knowledge Model. [PDF]

Adv Comput Vis Comput Biol (2020), 2021
Zhao MQ, Maldonado E, Kensler TB, Kohn LAP, Guatelli-Steinberg D, Wang Q.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Radiation Hardened LIDAR Sensor: Conceptual Design, Testing, and Performance Evaluation. [PDF]

Sensors (Basel)
Jonasson ET, Kuhlmann C, Wood C, Skilton R.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source