Results 121 to 130 of about 2,272,322 (296)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The influence of music environment on conceptual design creativity. [PDF]
Front Psychol, 2023 Xia T, Sun Y, An Y, Li L.
europepmc +1 more source
General purpose airborne simulator - Conceptual design report [PDF]
General purpose airborne simulator with capabilities for model controlled and response feedback types of variable stability ...
Clark, D. C., Kroll, J.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Conceptual Design of a Device for Online Calibration of Spirometer Based on Neural Network. [PDF]
J Biomed Phys Eng, 2023 Nafisi VR, Eghbal M, Torbati N.
europepmc +1 more source
Lean, premixed, prevaporized combustor conceptual design study [PDF]
Phase 1 of the Lean Premixed-Prevaporized Comubstor Design Study is a nine month analytical study effort with no experimental or testing activities included.
Ekstedt, E. E.
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
GOMEA: A Conceptual Design of a Membrane Electrode Assembly for a Proton Exchange Membrane Electrolyzer. [PDF]
Membranes (Basel), 2023 Berning T, Bessarabov D.
europepmc +1 more source
Conceptual design of an orbital debris collector [PDF]
The current Lower Earth Orbit (LEO) environment has become overly crowded with space debris. An evaluation of types of debris is presented in order to determine which debris poses the greatest threat to operation in space, and would therefore provide a ...
Brenton, Brian +5 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source