Results 121 to 130 of about 299,575 (258)

Conceptual Design of the "Private Car" Self-Isolation Ecosystem for the 2019-nCoV Infection. [PDF]

Int J Environ Res Public Health, 2022
Wang Y, Wang L, Wu X, Ding Z, Zheng W, Liang X, An H.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

AN EDUCATIONAL APPLICATION FOR A PRODUCT DESIGN AND ENGINEERING SYSTEMS USING INTEGRATED CONCEPTUAL MODELS UNA APLICACIÓN EDUCACIONAL PARA EL DISEÑO DE PRODUCTOS Y SISTEMAS DE INGENIERÍA UTILIZANDOMODELOS CONCEPTUALES INTEGRADOS

Ingeniare: Revista Chilena de Ingeniería, 2009
This article describes the use and application of a new methodology that has been developed for the conceptual design of new products, which emphasizes those innovating characteristics in design processes, thus fostering creative development.
Bernabé Hernandis Ortuño, Juan Carlos Briede Westermeyer   +1 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Conceptual design of the Hybrid Ring with superconducting linac. [PDF]

J Synchrotron Radiat, 2022
Harada K, Funamori N, Yamamoto N, Shimosaki Y, Shimada M, Miyajima T, Umemori K, Sakai H, Nakamura N, Sakanaka S, Kobayashi Y, Honda T, Nozawa S, Nakao H, Niwa Y, Wakabayashi D, Amemiya K, Igarashi N.   +17 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Evaluation of product conceptual design based on Pythagorean fuzzy set under big data environment. [PDF]

Sci Rep, 2022
Ma LD, Wang WX, Xie JW, Zhang N, Hu NF, Wang ZA.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A semantic analysis-driven customer requirements mining method for product conceptual design. [PDF]

Sci Rep, 2022
Wu XY, Hong ZX, Feng YX, Li MD, Lou SH, Tan JR.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source