Results 101 to 110 of about 2,272,322 (296)

An approach to machine tools structure selection for wooden product machining based on evidence networks [PDF]

open access: yesFME Transactions, 2016
During the product development phase, especially in the case of innovative products, designers used to face the unpleasant situation to be obliged to take decisions under conditions which are characterized by a relevant degree of uncertainty and even ...
Đapić Mirko, Lukić Lj., Pavlović A.
doaj  

Advanced heat receiver conceptual design study [PDF]

open access: yes
Solar Dynamic space power systems are candidate electrical power generating systems for future NASA missions. One of the key components of the solar dynamic power system is the solar receiver/thermal energy storage (TES) subsystem.
Batchelder, Gary   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

DESIGN, MODELLING AND SIMULATION OF A GRILL-ROTISSERIE ASSEMBLY

open access: yesJournal of Industrial Design and Engineering Graphics, 2021
This paper proposes the conceptual design and modelling by iterative improvements of two concepts of grill-rotisserie assembly, based on the idea of multifunctionality.
Cosmin-Gabriel BIRZU, Daniel DOBRE
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Conceptual design study report [PDF]

open access: yes
Conceptual design of Northrop V/STOL jet operations research supersonic ...

core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Solar sustained plasma/absorber conceptual design [PDF]

open access: yes
A space power system concept was evaluated which uses concentrated solar energy to heat a working fluid to temperatures as high as 4000 K. The high temperature working fluid could be used for efficient electric power production in advanced thermal or ...
Kendall, J. S.   +2 more
core   +1 more source

Methods and tools for supporting industrial design innovation [PDF]

open access: yes, 2008
The introduction of information technology (IT) systems to support designers’ activities and data management have profoundly affected company structure and design organization.
Carulli, Marina, Viganò, Roberto
core  

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