Results 81 to 90 of about 2,272,322 (296)
Wabu Gadun Bulmba Gurriny Mukanji Centre: A Case Study of Intercultural Design Practice
eTropic: electronic journal of studies in the tropics, 2014 In 2011 GudjuGudju Fourmile, elder of the Gimuy Walubara Yidinij people, asked me to work with him, as an architect, on the conceptual design for a facility for Indigenous people with acquired brain injury.
Shaneen Fantin, GudjuGudju Fourmile
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Engineering ProceedingsFoldable wing designs are becoming increasingly popular due to their advantages in the rapid deployment and compact packaging of fixed-wing UAVs, particularly when compared to horizontal take-off and VTOL counterparts.
Eleftherios Karatzas +5 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Novel Computer-Aided Design-Based Collaboration Framework for the Conceptual–Embodiment Design Phase
DesignsCollaborative production is growing in its importance to the global economy, and along with it, so are other collaborative activities along the production chain, such as collaborative design. Nowadays, collaborative detail design can be implemented using
Fariz Muharram Hasby +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
DronesDespite decades of development, micro air vehicles (MAVs) still face challenges related to endurance. While solar power has been successfully implemented in larger aircraft as a clean and renewable source of energy, its adaptation to MAVs presents unique
Weicheng Di +6 more
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Winged cargo return vehicle conceptual design [PDF]
NASA is committed to placing a permanent space station in Earth orbit in the 1990's. Space Station Freedom (SSF) will be located in a 220 n.m. orbit at 28.5 degrees inclination.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source