Results 71 to 80 of about 2,272,322 (296)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Conceptual modeling in architecture: a creative and educational resource
АрхитектонConceptual modeling is considered as a method of design activity and as a means of developing creative thinking in the process of architectural design.
Iovlev Valery I.
doaj +1 more source
Conceptual design optimization study [PDF]
The feasibility of applying multilevel functional decomposition and optimization techniques to conceptual design of advanced fighter aircraft was investigated.
Beeman, E. R., II +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Block 2 SRM conceptual design studies. Volume 1, Book 1: Conceptual design package [PDF]
The conceptual design studies of a Block 2 Solid Rocket Motor (SRM) require the elimination of asbestos-filled insulation and was open to alternate designs, such as case changes, different propellants, modified burn rate - to improve reliability and ...
Doll, Dan +8 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Conceptual Design Algorithm of Dousti Manned Spacecraft [PDF]
فصلنامه علوم و فناوری فضایی, 2012 To design a manned spacecraft carrying one to two crews to the low Earth orbits, design phases should be completed in various levels. It also needs to gather manned spacecrafts technical data which is developed in the same category.
M. Mirshams, L.. Khalaj-Zade
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2017 Generation of new concepts in product design process serves as driving force of innovation. While many methods have been proposed for supporting design concept generation, it has rarely been supported in a systematic way, because its process is done in ...
Yutaka NOMAGUCHI +2 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source