Results 71 to 80 of about 299,575 (258)

Conceptual modeling in architecture: a creative and educational resource

Архитектон
Conceptual modeling is considered as a method of design activity and as a means of developing creative thinking in the process of architectural design.
Iovlev Valery I.
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Management of Information and Infrastructure of Indigenous Community at Royal Belum State Park Using Geographical Information System: A Conceptual Design

Asian Journal of Technology Management, 2015
. Nowadays, an integrated location, descriptive inventory data and geographical information are required for a better decision making in Indigenous community management activities.
Othman Zainon
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conceptual frame design by heuristicly refined multiobjective random search [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2005
The use of mathematical optimisation methods in the engineering design process has traditionally been restricted to the detailed design stage. Using the design of a frame structure as a case study, this paper explores the potential of a heuristicly ...
Apichart Suppapitnarm
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Preliminary Correlations for Remotely Piloted Aircraft Systems Sizing

Aerospace, 2018
The field of Remotely Piloted Aircraft Systems (RPAS) is currently undergoing a noteworthy expansion. The diverse types of missions that these aircraft can accomplish, both in military and civil environments, have motivated an increase of interest in ...
Álvaro Gómez-Rodríguez, Alejandro Sanchez-Carmona, Luis García-Hernández, Cristina Cuerno-Rejado   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Wing Design for Class I Mini Unmanned Aerial Vehicles—Special Considerations for Foldable Wing Configuration at Low Reynolds Numbers

Engineering Proceedings
Foldable wing designs are becoming increasingly popular due to their advantages in the rapid deployment and compact packaging of fixed-wing UAVs, particularly when compared to horizontal take-off and VTOL counterparts.
Eleftherios Karatzas, Eleftherios Nikolaou, Antonis Pitsis, Spiridon Alexopoulos, Vaios Lappas, Vassilis Kostopoulos   +5 more
doaj   +1 more source