Results 61 to 70 of about 329,719 (257)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Conceptual design: Dependence of parameterization on design performance of three-stage hybrid rocket

Journal of Fluid Science and Technology, 2014
The subject of this paper is to improve on parameterization for conceptual design method of three stage hybrid rocket. Multi-Objective Genetic Algorithm (MOGA) is employed to solve multi-disciplinary design exploration of a three-stage launch vehicle ...
Masahiro KANAZAKI, Fumio KANAMORI, Yosuke KITAGAWA, Masaki NAKAMIYA, Koki KITAGAWA, Toru SHIMADA   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Preliminary Development of a Free Piston Expander–Linear Generator for Small-Scale Organic Rankine Cycle (ORC) Waste Heat Recovery System

Energies, 2016
A novel free piston expander-linear generator (FPE-LG) integrated unit was proposed to recover waste heat efficiently from vehicle engine. This integrated unit can be used in a small-scale Organic Rankine Cycle (ORC) system and can directly convert the ...
Gaosheng Li, Hongguang Zhang, Fubin Yang, Songsong Song, Ying Chang, Fei Yu, Jingfu Wang, Baofeng Yao   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Wing Design for Class I Mini Unmanned Aerial Vehicles—Special Considerations for Foldable Wing Configuration at Low Reynolds Numbers

Engineering Proceedings
Foldable wing designs are becoming increasingly popular due to their advantages in the rapid deployment and compact packaging of fixed-wing UAVs, particularly when compared to horizontal take-off and VTOL counterparts.
Eleftherios Karatzas, Eleftherios Nikolaou, Antonis Pitsis, Spiridon Alexopoulos, Vaios Lappas, Vassilis Kostopoulos   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Efficient Methodology for Power Management Optimization of Hybrid-Electric Aircraft

Aerospace
This paper presents an effective simplified model to optimize the mission power management supply for hybrid-electric aircraft in the conceptual design phase.
Giuseppe Palaia, Karim Abu Salem, Erasmo Carrera   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source