Results 61 to 70 of about 2,272,322 (296)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Adaptive high-performance and multifunctional façade systems
Frontiers in Built EnvironmentAdaptive, high-performance and multifunctional façades are recognized as key contributors to the EU’s climate-neutral agenda, as outlined in Directive (EU) 2024/1275, the Renovation Wave, and Horizon Europe initiatives.
Maria Matheou +3 more
doaj +1 more source
Human-centred design: An emergent conceptual model [PDF]
, 2009 (Human-centred design: an emergent conceptual module by Zhang T and Dong H) Understanding human needs and how design responds to human needs are essential for human-centred design (HCD).
Dong, H, Zhang, T
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Deformability of perforated bending-active façade plates
Frontiers in Built EnvironmentAdaptive building envelope systems are increasingly investigated for their potential to enhance environmental performance and architectural flexibility.
Charis Sergidis +2 more
doaj +1 more source
The Methodological Unboundedness of Limited Discovery Processes
FORMakademisk, 2014 Though designers must understand systems, designers work differently than scientists in studying systems. Design engagements do not discover whole systems, but take calculated risks between discovery and intervention.
John Benjamin Cassel
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Architecture, Civil Engineering, EnvironmentThis paper showcases three selected student projects on adaptive kinetic facades (AKFs) from the design studio “Smart Shade”, highlighting their influence on visual comfort, an essential component of occupants’ wellbeing and energy efficiency. Three case
Matheou Maria, Phocas Marios C.
doaj +1 more source