Results 51 to 60 of about 299,575 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conceptual Design of the Low-Cost Environmental Temperature Test Chamber System

International Journal of Engineering and Management Sciences, 2022
Unmanned robots being remotely controlled or autonomous are spread worldwide and used in different purposes. Inhabited robots are brought very close to users and accessibility to these tools is very high, moreover, at very low costs.
József Menyhárt, Róbert Szabolcsi
doaj   +1 more source

Conceptual design of financial ontology [PDF]

Annals of Computer Science and Information Systems, 2015
The article presents the approach to the conceptualization of the financial knowledge used for an Intelligent Dashboard for Managers. The content of the knowledge is focused on essential financial concepts and relationships related to the management of small and medium enterprises (SME).
Helena Dudycz, Jerzy Korczak 0001
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of a two-stage mixing process on the characteristics of concrete: Part I - Hardened concrete characteristics

Results in Materials
Mixing is an often overlooked aspect in the concrete production process, yet, it has a major impact on the concrete characteristics. This research investigates how different mixing methods affect the hardened concrete characteristics across four distinct
Alexander Teichmann, Benedikt Strahm, Harald Garrecht, Lucio Blandini   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigation of Pressure Chambers for Integrated Fluidic Actuators in Adaptive Slabs

Actuators
A high proportion of the CO2 emissions worldwide are caused by the construction sector or are associated with buildings. Every part of the industry needs to reduce its share of emissions, so the building sector must also do its part.
Matthias J. Bosch, Markus Nitzlader, Matthias Bachmann, Hansgeorg Binz, Lucio Blandini, Matthias Kreimeyer   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source