Results 31 to 40 of about 329,719 (257)
Frontiers in Energy Research, 2023 Heat pipe cooled reactors (HPCRs) have broad application prospects due to their advantages, such as high power density, compact structure, lower cost, and easy modular assembly.
Enpei Wang, Tingwei Ren, Lei Li
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Design for values and conceptual engineering
Ethics and Information Technology, 2023 Politicians and engineers are increasingly realizing that values are important in the development of technological artefacts. What is often overlooked is that different conceptualizations of these abstract values lead to different design-requirements. For example, designing social media platforms for deliberative democracy sets us up for technical work
Herman Veluwenkamp, Jeroen van den Hoven
openaire +3 more sources
Technical Notes and Manuals, 2010 This technical note describes need of conceptual design as a critical element of a government financial management information system project. Governments are increasingly turning to computerized financial management systems to help them respond to the demand for better information.
Abdul Khan, Mario Pessoa
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Results in MaterialsMixing is an often overlooked aspect in the concrete production process, yet, it has a major impact on the concrete characteristics. This research investigates how different mixing methods affect the hardened concrete characteristics across four distinct
Alexander Teichmann +3 more
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Optimization Framework for Early Conceptual Design of Helicopters
Aerospace, 2022 This work illustrates how a proposed method can be used to create optimization frameworks for early conceptual design studies and to increase overall knowledge at an early design stage.
Ludvig Knöös Franzén +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Investigation of Pressure Chambers for Integrated Fluidic Actuators in Adaptive Slabs
ActuatorsA high proportion of the CO2 emissions worldwide are caused by the construction sector or are associated with buildings. Every part of the industry needs to reduce its share of emissions, so the building sector must also do its part.
Matthias J. Bosch +5 more
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