Results 111 to 120 of about 2,272,322 (296)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A conceptual design of circular adaptive façade module for reuse. [PDF]
Sci Rep, 2023 Niazy D +4 more
europepmc +1 more source
Hybrid receiver conceptual design and test report [PDF]
The Hybrid Receiver described uses an acquisition and demodulation scheme tailored to the Jovian environment. The large Doppler offsets expected during initial acquisition led to development of the Hilbert Acquisition Aid, which provides for rapid ...
Crawford, J. J., Klare, S. W.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Lunar lander conceptual design [PDF]
This paper is a first look at the problems of building a lunar lander to support a small lunar surface base. A series of trade studies was performed to define the lander. The initial trades concerned choosing number of stages, payload mass, parking orbit
Adorjan, A. S. +9 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Conceptual Design and Numerical Validation of a Carbon-Based Ink Injector. [PDF]
Materials (Basel), 2023 Ortega-Gutiérrez A +6 more
europepmc +1 more source
Conceptual design of an in-space cryogenic fluid management facility, executive summary [PDF]
The conceptual design of a Spacelab experiment to develop the technology associated with low gravity propellant management is summarized. The preliminary facility definition, conceptual design and design analysis, and facility development plan, including
Hustvedt, D. C. +2 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Application of the generalized reduced gradient method to conceptual aircraft design [PDF]
The complete aircraft design process can be broken into three phases of increasing depth: conceptual design, preliminary design, and detail design. Conceptual design consists primarily of developing general arrangements and selecting the configuration ...
Gabriele, G. A.
core +1 more source