Results 111 to 120 of about 329,719 (257)

Implementation of Component-based Simulation Support Tool for Conceptual Design

open access: yesActa Polytechnica, 2004
Presented paper speaks about the problem of conceptual design stage simulation support. Simulation support is a very useful part of conceptual design system due to capability to verify ideas in early design stages.
T. Brandejský
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Concept Design and Reliability

open access: yesActa Polytechnica, 2002
The paper outlines an approach to concept design that integrates the development of the design specification with multi-objective concept development. ‘Excursions’ are undertaken to explore particular aspects of the design, e.g., reliability, in order to
G. Cooper, G. Thompson
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Conceptual Design of the "Private Car" Self-Isolation Ecosystem for the 2019-nCoV Infection. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Wang Y   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Conceptual design of the Hybrid Ring with superconducting linac. [PDF]

open access: yesJ Synchrotron Radiat, 2022
Harada K   +17 more
europepmc   +1 more source

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