Results 31 to 40 of about 270,662 (239)
Buildings, 2021 The design of a building façade has a significant impact on the way people respond to it physiologically and behaviourally. Few methods are available to assist an architect to understand such impacts during the design process.
Ju Hyun Lee, Michael J. Ostwald
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Integrated fluidic actuators for two-way concrete slabs
Applications in Engineering ScienceThe architecture, engineering and construction (AEC) field influences the anthropogenic CO2 footprint. Concrete is one of the most widely used materials, with cement production alone being responsible for 6–10 % of worldwide anthropogenic CO2 emissions ...
Matthias J. Bosch +5 more
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STATUS OF THE ASTRID CORE AT THE END OF THE PRE-CONCEPTUAL DESIGN PHASE 1
Nuclear Engineering and Technology, 2013 Within the framework of the ASTRID project, core design studies are being conducted by the CEA with support from AREVA and EDF. The pre-conceptual design studies are being conducted in accordance with the GEN IV reactor objectives, particularly in terms ...
MS. CHENAUD +16 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Results in MaterialsMixing is an often overlooked aspect in the concrete production process, yet, it has a major impact on the concrete characteristics. This research investigates how different mixing methods affect the hardened concrete characteristics across four distinct
Alexander Teichmann +3 more
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Conceptual Design of a Modular Floating Multi-Purpose Island
Frontiers in Marine Science, 2021 The design of a modular floating multi-purpose island inherently involves interaction within a group with a large range of backgrounds such as engineering, architecture, sociology, climate modeling, and more.
Ingo Drummen, Gerrit Olbert
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
From the herringbone dome by Sangallo to the Serlio floor of Emy (and beyond)
Curved and Layered Structures, 2021 The research starts from an analogy found between two apparently very different structural solutions: the double spiral pattern of the herringbone brick courses in the domes built by Antonio da Sangallo the Younger (1484-1546) during the Renaissance, and
Roberti Giulio Mirabella +2 more
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source