Results 131 to 140 of about 2,241,486 (282)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Emergence of ethnic entrepreneurship: a conceptual framework [PDF]

Dit rapport geeft inzicht in de toenemende groei van het aantal startende etnische ondernemers. Met behulp van een model wordt een beeld geschetst van de rol van de donorgroep (groep waarbinnen de starter leeft/werkt) waarin de bedrijven worden gestart.
Belaid Rettab, Belaid Rettab
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development trajectories of river basins: a conceptual framework [PDF]

River basin development / Water use / Water demand / Water supply / Water scarcity / Water allocation / Water conservation / Farm ponds / Tanks / Reservoirs / Irrigation management / Water use efficiency / Aquifers ...
Molle, F.
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Managing CSR Stakeholder Engagement: A New Conceptual Framework [PDF]

, 2014
A Crane, A Crane, A Crane, A Fischer, A Gini, A Habisch, A Lindgreen, A Peters, A. Roddick, AB Carroll, AB Carroll, AB Carroll, AO Laplume, B Donaldson, B Obama, B O’Dwyer, BR Agle, C Fraser, C Robson, CWL Hill, D Esteban, D Matten, D Secchi, D Silberhorn, E Garriga, F Maon, G Hardin, GM Zinkhan, H Deresky, I Maignan, J Burchell, J Burchell, J Daniels, J Elkington, J Frooman, J Jonker, J Pfeffer, Jenny Fairbrass, JP Doh, K Eisenhardt, K Homann, KB Murray, L Albareda, L O’Riordan, Linda O’Riordan, LK Trevino, LK Trevino, M Granovetter, M Greenwood, M Greenwood, M Jensen, M Wagner, MD Lee, ME Porter, ME Porter, ME Porter, MP Miles, MS Schwartz, OC Ferrell, P Hawken, P Kotler, P Kotler, PM Blau, R Hahn, R Phillips, R Phillips, R Welford, RA Spinello, RE Freeman, RE Freeman, RK Mitchell, RM Grant, S May, S Waddock, T Maak, W Visser, WBCSD   +76 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Transition Policy: A Conceptual Framework [PDF]

Legal change, whether through legislation, regulation, or court decision, is a common phenomenon, and virtually all reform creates both gains and losses for those who under the prior regime took actions that would have lasting effects.
Louis Kaplow
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source