Strategic Control for a U.K. Regional Health Authority: A Conceptual Framework [PDF]
, 1978 Mark Cantley
openalex
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Violent Politics of Informal Work, and How Young People Navigate Them: A Conceptual Framework
, 2016 Marjoke Oosterom +3 more
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Supporting Crowd-Powered Science in Economics: FRACTI, a Conceptual\n Framework for Large-Scale Collaboration and Transparent Investigation in\n Financial Markets [PDF]
, 2018 Jorge Faleiro, Edward Tsang
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A Conceptual Framework for the Application of Blockchain in Geospatial Sciences for Crisis Management. [PDF]
Mina Rezaeian, I. Najafi
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Tackling Health Disparities in Radiology: A Practical Conceptual Framework
, 2022 Marissa B. Lawson +4 more
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Conceptual framework for lean construction ambidexterity in project-based organizations
, 2021 Yanqing Fang +2 more
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FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source