Results 61 to 70 of about 652,386 (321)

An interdisciplinary theory of implementation, embedding and integration: the development of normalization process theory [PDF]

, 2009
Background: Theories are important tools in the social and natural sciences. The methods by which they are derived are rarely described and discussed. Normalization Process Theory explains how new technologies, ways of acting, and ways of working become ...
Christopher Dowrick, Montori Victor M, Mair, F., Ong, Bie, Treweek, S, Murray, E, Legare, F., May, C.R., Dowrick, Christopher, Ballini, L., Dowrick Christopher, Frances Mair (3498407), Treweek Shaun, Legare, F, May, CR, MacFarlane, A, Carl R. May (7784444), Luciana Ballini (12597781), Elwyn, G, Anne E. MacFarlane (12592810), Carl R May, Anne MacFarlane, Montori, Victor M, Montori, VM, France Légaré (2551459), Shaun Treweek, Dowrick, C., Victor M Montori, Mair, Frances, Murray, E., Dowrick, C, Rogers, A, Finch, Tracy, Treweek, Shaun, Gunn, J., Christopher Dowrick (3489197), Bie Nio Ong, Ong, Bie N., Légaré France, Montori, Victor M., Tim Rapley, Rogers, A., May, Carl R, Elwyn, G., Ong Bie, Rapley Tim, Shaun Treweek (62880), May, Carl, Victor M Montori (6685268), Murray, Elizabeth, Tracy Finch (3497930), Anne Rogers, Glyn Elwyn (36478), Ballini, Luciana, Finch, T, Rapley, T, Ong, BN, Gunn, J, Gunn Jane, Mair Frances, Legare, France, Mair, F, May, Carl R., Jane Gunn, MacFarlane, A., Murray Elizabeth, Elizabeth Murray, Montori, Victor, Luciana Ballini, Nio Ong, Bie, Rapley, Tim, Finch Tracy, MacFarlane, Anne, Montori, V.M., Elwyn Glyn, MacFarlane, Anne E., Anne Rogers (397640), Ballini, L, Treweek, S., May Carl R, Ong, Bie Nio, Frances Mair, Tracy Finch, Tim Rapley (3435371), France Légaré, Gunn, Jane, Ballini Luciana, Finch, T., Jane Gunn (21050), Glyn Elwyn, MacFarlane Anne, Ong, B.N., Elizabeth Murray (227943), Rogers, Anne, Elwyn, Glyn, Rogers Anne, Bie Nio Ong (41525), Rapley, T.   +97 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

"The Sociology of European Integration" [PDF]

, 2007
[From the introduction]. In recent critical literature reviews we have attempted to round up and summarise the existing ‘sociological’ style literature, as well as point to new and ongoing work that seems to advance a new agenda for sociology in EU ...
Guiraudon, Virginie,, Favell, Adrian.
core  

Grammatical Conceptualization as a Poetic Strategy in E. E. Cummings' yes is a pleasant country

Miscelánea: A Journal of English and American Studies, 2003
This article applies the theoretical principles of cognitive linguistics to E.E. Cummings’ poetic composition yes is a pleasant country. It combines the perspectives of conceptual metaphor theory, blending theory and the conceptual integration network ...
Pilar Alonso Rodríguez
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Representation and structuring of knowledge in the semantic oriented computing environment. Part 1. Integration conceptual graphs and logical networks based on formalization of structured situations

Известия высших учебных заведений. Поволжский регион:Технические науки, 2023
Background. A technique for deep knowledge structuring in a semantic-oriented intelligent computing environment based on the expansion of the descriptive capabilities of Petri nets by integrating them with conceptual graphs is proposed.
V.I. Volchikhin, N.S. Karamysheva, M.A. Mitrokhin, S.A. Zinkin   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Putting theory into practice: The creation of REALs in the context of today's universities [PDF]

, 1999
Rich Environments for Active Learning (REALs), as described by R. Scott Grabinger and Joanna Dunlap, are comprehensive educational systems based on constructivist principles that present an intellectual and practical challenge to university lecturers. As
Hancock, John, Kitts, Sally, Kitts, S-A, Hancock, JT   +3 more
core   +1 more source

Combinatorial Syntagmatics: from the Theory of Valency to the Theory of Conceptual Integration

Scientific Journal of National Pedagogical Dragomanov University. Series 9. Current Trends in Language Development, 2018
The topical and complicated problem of modern linguistics has been examined in the article. It deals with the study of the processes and mechanisms of creating new senses by the various combinations of both language signs among themselves and the transformation of the meanings of ready-made signs.
openaire   +2 more sources