Results 81 to 90 of about 9,203,387 (281)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Meaning Construction of Personification in Discourse Based on Conceptual Integration Theory [PDF]

, 2018
This article deals with meaning construction of personification in discourse from the standpoint of conceptual integration theory by drawing on examples from literary works, textbooks, other scholars’ articles and even websites.
LONG, Deyin
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Contributions of social capital to supply chain sustainability practices: Conceptual framework and propositions

Cleaner Logistics and Supply Chain
The integration of sustainability dimensions as part of supply chain management represents a constant challenge for companies. This happens because to address supply chain sustainability (SCS), companies need to know how collective behaviours are present
Gustavo Picanço Dias, Minelle E. Silva, Fernando Luiz Emerenciano Viana   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cognitive Study of XHY via Conceptual Integration Theory in English Teaching [PDF]

, 2016
Based on the conceptual integration theory, this thesis makes a cognitive analysis on the meaning construction of Chinese XHY. Particularly, the author conducts case studies at length of four pieces of XHY in accordance with the categories of conceptual ...
Wen, Jia
core   +1 more source

Halls of Fame across cultures: The figurative meaning of personal names in light of conceptual integration theory

ExELL (Explorations in English Language and Linguistics)
In recent years, a number of cognitive linguistic studies (Barcelona 2003, 2004, Brdar and Brdar-Szabó 2007, Brdar 2007) have focused on the construction of the figurative meaning of personal names as accompanied by their “irregular” morpho-syntactic ...
Sanja Berberović, Nihada Delibegović Džanić   +1 more
doaj  

Conceptual Framework for Integration of Organisation Information Processing Theory and Activity Theory in Enterprise Systems Implementation

, 2013
Los procesos de implementación de sistemas en las organizaciones siguen diferentes estrategias y una de estas estrategias es comprender las incertidumbres asociadas con la integración del nuevo sistema en un entorno de sistema existente para limitar cualquier desafío que pueda surgir durante la implementación del sistema.
Clement Mayieko Nyandiere, Faustin Kamuzora, Ismail Ateya Lukandu, Vincent Oteke Omwenga   +3 more
openaire   +3 more sources