Results 71 to 80 of about 9,203,387 (281)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Developing an Integrative Marketing Theory: Re-conceptualizing Valuation, Market Theory and Exchange [PDF]

International Journal of Accounting, Finance and Risk Management, 2018
Marketing specialists play a vanguard role in heralding a new perspective on exchange that prompts a re-conceptualization of valuation, marketing theory, and economic value theory. However the literature is inadequate in doing so in terms that are relevant for practitioners how the conceptualizations can be developed into a theoretical model for ...
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

What is advertising without blending? Advertisments in women’s magazines

ExELL (Explorations in English Language and Linguistics)
Conceptual integration theory, proposed by Fauconnier and Turner in 1993, has been successfully used in the study of a wide range of phenomena of human thought and action, from counterfactuals to met-aphors, proving blending to be present in the ...
Nihada Delibegović Džanić, Alma Žerić   +1 more
doaj  

Digital sustainability: Dimension exploration and scale development

Acta Psychologica
Digital sustainability is crucial in helping businesses achieve Sustainable Development Goals by integrating digitalization with sustainability to promote green growth.
Yixuan Wang, Ying Yu, Asif Khan
doaj   +1 more source

L’analyse des textes sur l’inclusion scolaire (depuis 1975) permet-elle de modéliser une évolution théorique du processus intégratif des élèves en situation de handicap à l’école et en EPS ?

eJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2013
The aim of this study is to analyze the official documents on the school integration (in general), and integration in Physical Education (in particular) of students with disabilities in France, since 1975.
Maxime Tant, Eric Watelain, Béatrice Carnel, Stéphane Watte   +3 more
doaj   +1 more source

Psychological theories of car use: An integrative review and conceptual framework

Journal of Environmental Psychology, 2018
Abstract Personal car use is increasing globally and is an important contributor to poor air quality and global greenhouse gas emissions. Although individuals have little direct control over some emission sources (e.g. heavy industry), they can modify their car use thereby reducing their own contribution.
Samuel Chng, Charles Abraham, Mathew P. White, Christin Hoffmann, Stephen Skippon   +4 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source