Results 121 to 130 of about 3,810,721 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Product design-Process selection-Process planning Integration based on Modelling and Simulation [PDF]

, 2014
As a solution for traditional design process having many drawbacks in the manufacturing process, the integration of Product design-Process selection-Process planning is carried out in the early design phase.
MARTIN, Patrick, CROUE, Jean-Baptiste, LANGLOIS, Laurent, NGUYEN, Von Dim   +3 more
core  

Considerations on the basis of medical reasoning for the use in AI applications

Frontiers in Medicine
This study discusses the integration of artificial intelligence (AI) and machine learning (ML) in medical reasoning and decision-making, with a focus on the challenges and opportunities associated with the massive consumption of data required for ...
Adamantios Koumpis, Adam S. L. Graefe, Adam S. L. Graefe   +2 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Towards active conceptual modelling for sudden events [PDF]

, 2007
There are a number of issues for information systems which are required to collect data urgently that are not well accommodated by current conceptual modelling methodologies and as a result the modelling step (and the use of databases) is often ...
de Vries, Denise Bernadette, Roddick, John Francis, Ceglar, Aaron John   +2 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Critical Edition Ontology: a conceptual model for digital critical editions

Umanistica Digitale
Over the last thirty years, In the field of digital philology, several generic IT tools have been developed to produce digital scholarly editions (DSE). However, the majority of DSEs continue to be produced using custom-developed tools.
Chiara Martignano
doaj   +1 more source

Conceptual modelling styles

ITI 2002. Proceedings of the 24th International Conference on Information Technology Interfaces (IEEE Cat. No.02EX534), 2003
Three steps in data modelling include conceptual, logical and physical modelling. The conceptual modelling models data from the users&#8217 ; ; perspective independently from any logical and physical implementation. The paper discusses different conceptual modelling styles that may apply in modelling transactional and analytical information system.
openaire   +2 more sources