Results 111 to 120 of about 3,810,721 (302)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A conceptual framework for product lifecycle modeling
, 2006 Product lifecycle management (PLM) is a concept that aims at integrating the various processes and phases involved during a typical product lifecycle for the extended enterprise.
Zhang WL(张闻雷), Fan YS(范玉顺)
core
Endurant Types in Ontology-Driven Conceptual Modeling: Towards OntoUML 2.0 [PDF]
, 2018 For over a decade now, a community of researchers has contributed to the development of the Unified Foundational Ontology (UFO) - aimed at providing foundations for all major conceptual modeling constructs. This ontology has
Almeida J. P +17 more
core +1 more source
A conceptual model for megaprogramming [PDF]
ACM SIGSOFT Software Engineering Notes, 1991 " Currently, software is put together one statement at a time. What we need is to put software together one component at a time ." --- Barry Boehm, at the Domain Specific Software Architecture (DSSA) Workshop, July 11--12, 1990.Megaprogramming, as defined at the first ISTO Software Technology Community Meeting, June
openaire +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
How Conceptual Modeling Is Used [PDF]
, 2009 Conceptual models play an increasingly important role for business process engineering, information systems development, and customizing of Enterprise Resource Planning (ERP) systems.
Fettke, Peter
core +1 more source
Editorial: Model-centered software and system development
Frontiers in Computer Science, 2023 Heinrich C. Mayr, B. Thalheim
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Tailoring temporal description logics for reasoning over temporal conceptual models [PDF]
, 2011 Temporal data models have been used to describe how data can evolve in the context of temporal databases. Both the Extended Entity-Relationship (EER) model and the Unified Modelling Language (UML) have been temporally extended to design temporal ...
Ryzhikov, Vladislav +8 more
core +1 more source