Results 91 to 100 of about 854,269 (252)

Enable Flexibilisation in FAIRWork’s Democratic AI-based Decision Support System by Applying Conceptual Models Using ADOxx

Complex Systems Informatics and Modeling Quarterly
Decision-making in complex production environments is challenging as the information and knowledge requirements must be constantly observed since the ecosystems they operate in are continuously changing. Artificial intelligence (AI) can tackle complexity
Robert Woitsch, Christian Muck, Wilfrid Utz, Herwig Zeiner   +3 more
doaj   +1 more source

A Linguistic-Based Systematic Approach to Complex System Dynamics and its Application to E-government Introduction in Zanzibar

Complex Systems Informatics and Modeling Quarterly, 2017
System thinking has become an effective strategy when dealing with complex systems. Such systems are characterized by mutual interactions, causality and inter-dependency between system components. A typical example is the cooperation between governmental
Maryam M. Khamis, Theo P. van der Weide
doaj   +1 more source

COVID-19 Conceptual Modeling: Single-Center Cross-Sectional Study. [PDF]

JMIR Form Res, 2023
Abuauf M, Raboe EH, Alshareef M, Rabie N, Zailaie R, Alharbi A, Felemban W, Alnasser I, Shalaby H.   +8 more
europepmc   +1 more source

The Partial Evaluation Approach to Information Personalization [PDF]

, 2001
Information personalization refers to the automatic adjustment of information content, structure, and presentation tailored to an individual user. By reducing information overload and customizing information access, personalization systems have emerged ...
Perugini, Saverio, Ramakrishnan, Naren
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fostering engineering and science students' and teachers' systems thinking and conceptual modeling skills. [PDF]

Instr Sci, 2023
Peretz R, Tal M, Akiri E, Dori D, Dori YJ.   +4 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Bayesian Hierarchical Modelling for Tailoring Metric Thresholds

, 2018
Software is highly contextual. While there are cross-cutting `global' lessons, individual software projects exhibit many `local' properties. This data heterogeneity makes drawing local conclusions from global data dangerous.
Bettenburg N., Bob Carpenter, McIlreath Richard, Oliveira P., Panichella A.   +4 more
core   +1 more source