Results 91 to 100 of about 3,810,721 (302)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Conceptual Model Of Resolution
, 2017 In this document, we look at three aspects of the resolution of identifiers to a URI representing the resource: dynamic data citation, content negotiation, and machine-enabled licence information.
Fenner, Martin +2 more
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Quality in conceptual modeling - New research directions
, 2003 A
Geert Poels +8 more
core +1 more source
A Capability-Based Method for Modeling Resilient Data Ecosystems
, 2022 Modern information systems rely on data analytics and use various data sources to steer information processing and process execution activities. Capability-driven development is a method for the design and delivery of this kind of information systems ...
Grabis, Janis, +7 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Developing Data Workflows: From Conceptual Blueprints to Physical Implementation
DataData workflows are an important component of modern analytical systems, enabling structured data extraction, transformation, integration, and delivery across diverse applications. Despite their importance, these workflows are often developed using ad hoc
Bruno Oliveira, Óscar Oliveira
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Multilevel Modeling with ConceptBase [Elektronisk resurs]
, 2021 Multilevel modeling aims at improving the expressiveness and conciseness of conceptual modeling languages by allowing to express domain knowledge at higher abstractions levels.
Jeusfeld, Manfred A.,
core
COVID-19 Conceptual Modeling: Single-Center Cross-Sectional Study. [PDF]
JMIR Form Res, 2023 Abuauf M +8 more
europepmc +1 more source