Results 71 to 80 of about 3,810,721 (302)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The Conceptual LeanPPD Model [PDF]
, 2010 This paper is presenting the conceptual Lean Product and Process Development (LeanPPD) model which is a project funded by the EU-PF7. The project is addressing the needs of European manufacturing companies of a new model that goes beyond lean manufacturing, to ensure the transformation of the enterprise into lean environment.
Ahmed Al-Ashaab +8 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Heterogeneity in model management
, 2022 S.237-253As models are always abstractions of reality, we often need multiple modeling perspectives for analysis. The interplay of such modeling perspectives can take many forms and plays a role both at the design level, and during the operation of ...
Jarke, M. +3 more
core +1 more source
Multilevel Modeling with ConceptBase
, 2021 Multilevel modeling aims at improving the expressiveness and conciseness of conceptual modeling languages by allowing to express domain knowledge at higher abstractions levels.
Jeusfeld, Manfred A.
core +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A TERNARY CONCEPTUAL FRAMEWORK OF CRITICAL INFRASTRUCTURE RESILIENCE MANAGEMENT CYCLE
Надежность и качество сложных системBackground. The study considers hot-button issues of analysis and modeling of the critical infrastructure resilience cycle in order to engineering automated tools for management information support of the resilient functioning of these complex ...
A.V. Masloboev
doaj +1 more source
A conceptual spatio-temporal multidimensional model
Revista Ingenierías Universidad de Medellín, 2011 Today, thanks to global positioning systems technologies and mobile devices equipped with tracking sensors, and a lot of data about moving objects can be collected, e.g., spatio-temporal data related to the movement followed by objects.
Francisco Moreno +2 more
doaj
How to deal with Haplotype data: An Extension to the Conceptual Schema of the Human Genome
CLEI Electronic Journal, 2016 The goal of this work is to describe the advantages of the application of Conceptual Modeling (CM) in complex domains, such as genomics. Nowadays, the study and comprehension of the human genome is a major challenge due to its high level of complexity ...
José Fabián Reyes Román +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source