Results 71 to 80 of about 854,269 (252)

Relationships and events: towards a general theory of reification and truthmaking. [PDF]

, 2016
We propose a novel ontological analysis of relations and relationships based on a re-visitation of a classic problem in the practice of knowledge repre- sentation and conceptual modeling, namely relationship reification. Our idea is that a relation holds
Guarino, Nicola, Guizzardi, Giancarlo
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

System Methodology as a Conceptual Basis of Interdisciplinary and Transdisciplinary research

Управленческие науки, 2020
The paper is devoted to the methodological tasks of conducting transdisciplinary research of TI, that have been leading to the tasks of integrating the knowledge of various stakeholders.
S. G. Zbrishchak
doaj   +1 more source

Conceptual Spaces in Object-Oriented Framework [PDF]

, 2016
The aim of this paper is to show that the middle level of mental representations in a conceptual spaces framework is consistent with the OOP paradigm.
Gemel, Aleksander, Ishii, Tadao
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A TERNARY CONCEPTUAL FRAMEWORK OF CRITICAL INFRASTRUCTURE RESILIENCE MANAGEMENT CYCLE

Надежность и качество сложных систем
Background. The study considers hot-button issues of analysis and modeling of the critical infrastructure resilience cycle in order to engineering automated tools for management information support of the resilient functioning of these complex ...
A.V. Masloboev
doaj   +1 more source

Energy substitution, technical change and rebound effects [PDF]

, 2014
This paper investigates the relationships between energy efficiency improvements by producers, the ease of substitution between energy and other inputs and the size of the resulting “rebound effects”.
Allan, Apostolakis, Azar, Berndt, Berndt, Berndt, Berndt, Bhattacharyya, Binswanger, Blackorby, Bosetti, Broadstock, Burniaux, Christensen, Conrad, Edenhofer, Frondel, Frondel, Frondel, Frondel, Gerlagh, Glomsrod, Goulder, Grepperud, Hanley, Hertel, Hicks, Hogan, Hogan, Kemfert, Kemfert, Kermfert, Koetse, Lecca, Löschel, Manne, Manne, Manne, Manne, McFadden, Patterson, Popp, Raj, Sanstad, Sato, Sato, Saunders, Saunders, Saunders, Saunders, Saunders, Saunders, Sorrell, Stern, Steve Sorrell, Sue Wing, Sue Wing, Sue Wing, Turner, Van der Werf, Van der Zwaan   +60 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source