Results 71 to 80 of about 103,754 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Developing Data Workflows: From Conceptual Blueprints to Physical Implementation

Data
Data workflows are an important component of modern analytical systems, enabling structured data extraction, transformation, integration, and delivery across diverse applications. Despite their importance, these workflows are often developed using ad hoc
Bruno Oliveira, Óscar Oliveira
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

COVID-19 Conceptual Modeling: Single-Center Cross-Sectional Study. [PDF]

JMIR Form Res, 2023
Abuauf M, Raboe EH, Alshareef M, Rabie N, Zailaie R, Alharbi A, Felemban W, Alnasser I, Shalaby H.   +8 more
europepmc   +1 more source

Conceptual Model Of Resolution

, 2017
In this document, we look at three aspects of the resolution of identifiers to a URI representing the resource: dynamic data citation, content negotiation, and machine-enabled licence information.
Fenner, Martin, Petryszak, Robert, Kotarski, Rachael   +2 more
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Enable Flexibilisation in FAIRWork’s Democratic AI-based Decision Support System by Applying Conceptual Models Using ADOxx

Complex Systems Informatics and Modeling Quarterly
Decision-making in complex production environments is challenging as the information and knowledge requirements must be constantly observed since the ecosystems they operate in are continuously changing. Artificial intelligence (AI) can tackle complexity
Robert Woitsch, Christian Muck, Wilfrid Utz, Herwig Zeiner   +3 more
doaj   +1 more source

Selected Topics on Business Information Systems: Editorial Introduction to Issue 11 of CSIMQ

Complex Systems Informatics and Modeling Quarterly, 2017
Information and Communication Technology (ICT) plays an important role in enterprises, public authorities, inter-organizational networks, company clusters and other kinds of distributed organizations. Business, value creation and supporting activities in
Kurt Sandkuhl
doaj   +1 more source

Fostering engineering and science students' and teachers' systems thinking and conceptual modeling skills. [PDF]

Instr Sci, 2023
Peretz R, Tal M, Akiri E, Dori D, Dori YJ.   +4 more
europepmc   +1 more source