Results 61 to 70 of about 3,810,721 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A survey on the model-centered approaches to conceptual modeling of IoT systems

open access: yesFrontiers in Computer Science, 2023
Internet of Things (IoT) is a system of connected objects, entities, devices, and components which share and transfer data over a network. Many papers are published on the topic of conceptual models in the IoT context, but it is difficult to assess the ...
Sofia Kohan   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Un modelo multidimensional conceptual espacio-temporal A conceptual spatio-temporal multidimensional model

open access: yesRevista Ingenierías Universidad de Medellín, 2010
Hoy, gracias a los sistemas de posicionamiento global y dispositivos móviles equipados con sensores de rastreo, se puede recopilar una gran cantidad de datos sobre objetos móviles, es decir, datos espacio-temporales relacionados con el movimiento seguido
Francisco Moreno   +2 more
doaj  

Addressing complexity and uncertainty: conceptual models and expert judgments applied to migratory birds in the oil sands of Canada

open access: yesEcology and Society, 2015
Complexity and uncertainty are inherent in social-ecological systems. Although they can create challenges for scientists and decision makers, they cannot be a reason for delaying decision making.
Marc A. Nelitz   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Conceptual modeling - an epistemological foundation [PDF]

open access: yes, 2004
The success of contemporary organizations depends on their ability to make appropriate decisions. Making appropriate decisions is inevitably bound to the availability and provision of relevant information.
Niehaves, Bjorn   +4 more
core   +1 more source

A participative and facilitative conceptual modelling framework for discrete event simulation studies in healthcare [PDF]

open access: yes, 2013
Existing approaches to conceptual modelling (CM) in discrete-event simulation do not formally support the participation of a group of stakeholders. Simulation in healthcare can benefit from stakeholder participation as it makes possible to share multiple
Tako, A.A.   +8 more
core   +1 more source

CSIMQ Anniversary Editor-in-Chief Thoughts and Editorial Introduction to Issue 38: Model-based and Decision Support Methods for Next-generation Information Systems

open access: yesComplex Systems Informatics and Modeling Quarterly
The 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström   +2 more
doaj   +1 more source

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