Results 81 to 90 of about 854,269 (252)

Towards a Theory Grounded Theory of Language [PDF]

, 2002
In this paper, we build upon the idea of theory grounding and propose one specific form of theory grounding, a theory of language. Theory grounding is the idea that we can imbue our embodied artificially intelligent systems with theories by modeling the ...
Kosolapov, Oleksandr V., Lykken, Troy R., Mislivec, Eric J., Prince, Christopher G.   +3 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Graphic Thinking and Digital Processes: Three Built Case Studies of Digital Materiality [PDF]

, 2017
Think strategic link between computer programming; digital modeling; the data; matter and CNC manufacturing in the various stages of the architectural project is key to update our discipline with new technologies.
Castaño Perea, Enrique (Coordinador), Chiarella, Mauro, Echevarría, Ernesto (Coordinador), Martín Pastor, Andrés, Sáez, Nicolás   +4 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Developing Data Workflows: From Conceptual Blueprints to Physical Implementation

Data
Data workflows are an important component of modern analytical systems, enabling structured data extraction, transformation, integration, and delivery across diverse applications. Despite their importance, these workflows are often developed using ad hoc
Bruno Oliveira, Óscar Oliveira
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Selected Topics on Business Information Systems: Editorial Introduction to Issue 11 of CSIMQ

Complex Systems Informatics and Modeling Quarterly, 2017
Information and Communication Technology (ICT) plays an important role in enterprises, public authorities, inter-organizational networks, company clusters and other kinds of distributed organizations. Business, value creation and supporting activities in
Kurt Sandkuhl
doaj   +1 more source

Modeling Concept Combinations in a Quantum-theoretic Framework

, 2014
We present modeling for conceptual combinations which uses the mathematical formalism of quantum theory. Our model faithfully describes a large amount of experimental data collected by different scholars on concept conjunctions and disjunctions ...
A. Y. Khrennikov, D. Aerts, D. Aerts, D. Aerts, D. Aerts, D. Aerts, D. Aerts, D. Aerts, E. Haven, E. M. Pothos, J. A. Hampton, J. A. Hampton, J. R. Busemeyer, J. R. Busemeyer, S. Alxatib, S. Sozzo   +15 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source