Results 81 to 90 of about 3,810,721 (302)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Evaluation of Conceptual Modeling Languages. An Epistemological Discussion [PDF]
, 2005 The Information Systems (IS) discipline is coined by a multiplicity of available conceptual modeling approaches. Thus, evaluation techniques have been developed in order to assess the appropriateness of a conceptual model in a given context.
Recker, Jan, Recker, Jan C.
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System Methodology as a Conceptual Basis of Interdisciplinary and Transdisciplinary research
Управленческие науки, 2020 The paper is devoted to the methodological tasks of conducting transdisciplinary research of TI, that have been leading to the tasks of integrating the knowledge of various stakeholders.
S. G. Zbrishchak
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
International Journal of Computing, 2014 Decision making is mostly based on decision concepts and decision models built in decision support systems. Type of decision problem determines application. This paper presents a conceptual decision model that utilises rule- based methodologies, numerical algorithms and procedures, statistical methodologies including distributions, and visual support ...
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conceptual Modeling of Objects
CoRR, 2022 In this paper, we concentrate on object-related analysis in the field of general ontology of reality as related to software engineering (e.g., UML classes). Such a venture is similar to many studies in which researchers have enhanced modeling through ontological analysis of the underlying paradigm of UML models. We attempt to develop a conceptual model
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Temporal Conceptual Modeling of Workflows
, 2003 Business processes require the coordinated execution of simple activities (tasks) by human or automatic executors (agents). Business processes are described in terms of a work ow and their execution is supported by suitable software systems named work ...
COMBI, Carlo +5 more
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A Modeling Method in Support of Strategic Analysis in the Realm of Enterprise Modeling
, 2021 Organizations increasingly have to cope with the digital transformation, which is ubiquitous in today’s society. Strategic analysis is an important first step towards the success of digital transformation initiatives, whereby all the elements (e.g ...
Sybren de Kinderen, Monika Kaczmarek-Heß
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