Results 101 to 110 of about 3,810,721 (302)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Conceptual modeling ER 2004 : 23rd International Conference on Conceptual Modeling, Shanghai, China, November 8-12, 2004 ; proceedings

, 2004
xxi, 869 p. | fig., tab.
Atzeni, Paolo,, International Conference on Conceptual Modeling   +1 more
core  

Enable Flexibilisation in FAIRWork’s Democratic AI-based Decision Support System by Applying Conceptual Models Using ADOxx

Complex Systems Informatics and Modeling Quarterly
Decision-making in complex production environments is challenging as the information and knowledge requirements must be constantly observed since the ecosystems they operate in are continuously changing. Artificial intelligence (AI) can tackle complexity
Robert Woitsch, Christian Muck, Wilfrid Utz, Herwig Zeiner   +3 more
doaj   +1 more source

Selected Topics on Business Information Systems: Editorial Introduction to Issue 11 of CSIMQ

Complex Systems Informatics and Modeling Quarterly, 2017
Information and Communication Technology (ICT) plays an important role in enterprises, public authorities, inter-organizational networks, company clusters and other kinds of distributed organizations. Business, value creation and supporting activities in
Kurt Sandkuhl
doaj   +1 more source

Fostering engineering and science students' and teachers' systems thinking and conceptual modeling skills. [PDF]

Instr Sci, 2023
Peretz R, Tal M, Akiri E, Dori D, Dori YJ.   +4 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Anchor Modeling

, 2009
Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a ...
Rönnbäck, Lars, Lars Rönnbäck, Petia Wohed, Regardt, Olle,, Paul Johannesson, Wohed, Petia,, Regardt, Olle, Olle Regardt, Bergholtz, Maria,, Johannesson, Paul,, Ronnback, Lars,, Maria Bergholtz   +11 more
core   +1 more source

A Linguistic-Based Systematic Approach to Complex System Dynamics and its Application to E-government Introduction in Zanzibar

Complex Systems Informatics and Modeling Quarterly, 2017
System thinking has become an effective strategy when dealing with complex systems. Such systems are characterized by mutual interactions, causality and inter-dependency between system components. A typical example is the cooperation between governmental
Maryam M. Khamis, Theo P. van der Weide
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Conceptual Modelling of Services.

J. Univers. Comput. Sci., 2012
Conceptual Modelling of ...
Ma, Hui, Schewe, Klaus-Dieter, Thalheim, Bernhard, Wang, Qing (Ms)   +3 more
openaire   +3 more sources