Epidemiological Conceptual Models and Health Justice for Critically Ill Older Adults. [PDF]
Crit Care Med, 2021 Scheunemann LP, Girard TD, Leland NE.
europepmc +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Usability testing of a conceptual model through retrospective cross-case analysis
MethodsXQualitative conceptual models are commonly used in the scientific literature to make complex phenomena easier to understand. However, the effectiveness and usability of conceptual models to serve as analytical tools is rarely explored and tested, and ...
John Paul Mynott, Klara Kager
doaj +1 more source
Beyond the detection of students´ mental models. An integrative representational approach [PDF]
Investigações em Ensino de Ciências, 2002 In this paper we initially discuss some limitations of the mental model theoretical framework for research in science education. Then, after an analysis of Vergnaud´s conceptual fields theory we propose an approach that integrating elements of both ...
Ileana Maria Greca +1 more
doaj
Family as a health promotion setting: A scoping review of conceptual models of the health-promoting family. [PDF]
PLoS One, 2021 Michaelson V, Pilato KA, Davison CM.
europepmc +1 more source
Space Station Furnace Facility. Volume 2: Requirements definition and conceptual design study [PDF]
The Space Station Freedom Furnace (SSFF) Project is divided into two phases: phase 1, a definition study phase, and phase 2, a design and development phase.
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Agent-Based Models and Simulations in Economics and Social Sciences [PDF]
Now that complex Agent-Based Models and computer simulations spread over economics and social sciences - as in most sciences of complex systems -, epistemological puzzles (re)emerge.
Denis Phan, Franck Varenne
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source