Results 151 to 160 of about 8,079,181 (257)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Feedback Loops in Conceptual Models of Land Change: Lost in Complexity?

Ecology and Society, 2011
Anna M. Hersperger, Maria-Pia Gennaio, Peter H. Verburg, Matthias Bürgi   +3 more
doaj   +1 more source

Conceptual Models of Entrainment, Jet Lag, and Seasonality. [PDF]

Front Physiol, 2020
Tokuda IT, Schmal C, Ananthasubramaniam B, Herzel H.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

River ecosystem conceptual models and non-perennial rivers: A critical review. [PDF]

WIREs Water, 2020
Allen DC, Datry T, Boersma KS, Bogan MT, Boulton AJ, Bruno D, Busch MH, Costigan KH, Dodds WK, Fritz KM, Godsey SE, Jones JB, Kaletova T, Kampf SK, Mims MC, Neeson TM, Olden JD, Pastor AV, Poff NL, Ruddell BL, Ruhi A, Singer G, Vezza P, Ward AS, Zimmer M.   +24 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cognition Model in Conceptual Designing

, 2009
Both design researchers and cognitive scientists have developed various process models to study human creative behaviour in design. The models developed are often based on observations of design processes and analysis of design protocols.
W. Abdelhameed
core  

Obstacle negotiation in older adults: prefrontal activation interpreted through conceptual models of brain aging [PDF]

Innov Aging, 2020
Clark D, Chatterjee S, Seidler R, Skinner J, Rose D, Lysne P, Woods A.   +6 more
europepmc   +2 more sources

Reframing nociplastic pain research and treatment using post-traumatic stress disorder-inspired conceptual models. [PDF]

Pain
Coulombe-Leveque A, Bonin RP, Léonard G.   +2 more
europepmc   +1 more source