Results 151 to 160 of about 366,121 (313)

The notion of role in conceptual modeling

open access: yes, 1997
Dates de conf{\'e}rence : octobre 1997 ...
Chantal Reynaud   +3 more
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Supporting electronic collaboration in conceptual modeling

open access: yes, 2008
We study collaborative modeling by analyzing conversations and loud thinking during modeling sessions and the resulting models themselves. We identify the basic activities of the modeling teams on the social, pragmatic, semantic and syntactic levels and ...
Rittgen, Peter
core  

From Concept Models to Conceptual Data Models [PDF]

open access: yes, 2011
In order to develop a harmonised and efficient IT system, such as a database, it is important to be familiar with the underlying concept model (concept systems) for the relevant domain which the IT system should be designed to accommodate, as this forms ...
Nistrup Madsen, Bodil   +1 more
core  

Are conceptual models concept models?

open access: yes, 2013
The conceptual modelling community not only has no clear, general agreement on what its models model, it also has no clear picture of what the available options and their implications are.
Partridge, C   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Usability testing of a conceptual model through retrospective cross-case analysis

open access: yesMethodsX
Qualitative conceptual models are commonly used in the scientific literature to make complex phenomena easier to understand. However, the effectiveness and usability of conceptual models to serve as analytical tools is rarely explored and tested, and ...
John Paul Mynott, Klara Kager
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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