Results 161 to 170 of about 366,121 (313)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A conceptual framework for integrating ecosystem services and social welfare into flood hazard mitigation benefit–cost analysis

open access: yesEnvironmental Research: Infrastructure and Sustainability
Flood hazard mitigation and adaptation require the evaluation of structural, nonstructural, and nature-based projects across different scenarios. Traditional assessments have focused on reducing average annual structural losses, but new methods have ...
Fahmida Akhter   +5 more
doaj   +1 more source

How quickly do we learn conceptual models?

open access: yes, 2019
In organizations, conceptual models are used for understanding domain concepts. Learning the domain from models is crucial for the analysis and design of information systems that are intended to support the domain.
Bera, Palash, Poels, Geert
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Cognition Model in Conceptual Designing

open access: yes, 2009
Both design researchers and cognitive scientists have developed various process models to study human creative behaviour in design. The models developed are often based on observations of design processes and analysis of design protocols.
W. Abdelhameed
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

An exploratory analysis on the comprehension of 3D and 4D ontology-driven conceptual models

open access: yes, 2016
In this paper, we perform an exploratory analysis to investigate the impact of adopting a 3D and a 4D foundational ontology on the quality of a conceptual model.
Verdonck, MichaëlEB240000705909408020017536150000-0002-1927-315107F014EA-F0EE-11E1-A9DE-61C894A0A6B4   +3 more
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy