Results 31 to 40 of about 125,633 (265)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Indian Ocean as a Diasporic Space: A conceptual introduction
Journal of Indian Ocean World Studies, 2021 Over the past two decades there has been a growing interest in Indian Ocean networks within diaspora studies, and within migration studies more generally. In this introduction we develop the idea of the Indian Ocean as a space within which diasporas come
Iain Walker, Martin Slama
doaj +1 more source
Conceptual Spaces in ViCoS [PDF]
, 2008 We describe ViCoS, a tool for constructing and visualising conceptual spaces in the area of language documentation. ViCoS allows users to enrich existing lexical information about the words of a language with conceptual knowledge. Their work towards language-based, informal ontology building must be supported by easy-to-use workflows and supporting ...
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
"Conceptual Space ": an Approach to the Development of Semantic Web [PDF]
بازیابی دانش و نظامهای معنایی, 2017 Semantic Web as the third generation of the Web is due to greater interaction between humans and computers and attempts to understand the processing of information for the machine in order to establish relationships between Web pages in such a way as to ...
Khadijeh Moradi
doaj +1 more source
Forecasting the Attractiveness of Crowdsourced Ideas Using Natural Language Processing Techniques:
Maketingu Janaru, 2021 While it has been proven that product development using crowdsourcing can produce highly marketable products, it continues to be a heavy burden to evaluate the large volume of user-generated ideas and to select the most attractive ones. In this study, we
Seiichiro Honjo, Tomohiro Ito
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Space and Time in the Child’s Mind: Metaphoric or ATOMic?
Frontiers in Psychology, 2013 Space and time are intimately linked in the human mind, but different theories make different predictions about the nature of this relationship. Metaphor Theory (MT) predicts an asymmetric relationship between space and time.
Roberto eBottini, Daniel eCasasanto
doaj +1 more source