Results 61 to 70 of about 306,552 (260)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

5E-Learning Cycle Strategy: Increasing Conceptual Understanding and Learning Motivation

Jurnal Ilmiah Pendidikan Fisika Al-Biruni, 2018
5E learning cycle strategy was students center oriented learning model. The learning process becomes more meaningful, which are prioritized authentic experience of students, made students become actively participating, able to critical thinking skills ...
Febrianto Putra, Ika Yunita Nur Kholifah, Bambang Subali, Ani Rusilowati   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Kinematics Conceptual Understanding: Interpretation of Position Equations as a Function of Time

Jurnal Pendidikan Sains, 2018
: This article aims at describing the ability of 48 students of physics education in determining the distance traveled, average speed, and acceleration of position functions. To achieve these objectives, three reasoned multiple choice questions were used.
Muhammad Reyza Arief Taqwa, Lugy Rivaldo
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

UNDERSTANDING THE CONCEPT AND MISCONCEPTION OF STUDENT TEACHER IN KEPLER'S LAWS

Jurnal Kependidikan: Penelitian Inovasi Pembelajaran, 2019
PEMAHAMAN KONSEP DAN MISKONSEPSI MAHASISWA CALON GURU PADA HUKUM KEPLER Abstrak Penelitian ini bertujuan untuk menginvestigasi tingkat pemahaman konsep dan miskonsepsi mahasiswa calon guru pada hukum Kepler.
Syuhendri Syuhendri, Nely Andriani, Saparini Saparini   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Analysis of Students' Conceptual Understanding of Logarithm Application Problems Based on Self-Efficacy

Kreano: Jurnal Matematika Kreatif-Inovatif
Understanding the concept of logarithms is an essential perspective of self-efficacy gaps, as it influences students' problem-solving confidence and willingness to learn.
Muhammad Muzaini, Nasrun Nasrun
doaj   +1 more source