Results 81 to 90 of about 306,552 (260)

Addressing mathematics learning challenges through concept-based instruction

LUMAT
Continuous poor performance of learners in mathematics motivated the study reported in this paper. The purpose of the study was to investigate the challenges that concept-based instruction could address in trying to improve learners’ performance in ...
Mildret Ncube, Kakoma Luneta
doaj   +1 more source

How do enhanced videos support generative learning and conceptual understanding in individuals and groups? [PDF]

Educ Technol Res Dev, 2023
Ruf A, Zahn C, Roos AL, Opwis K.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The division of linguistic labour for offloading conceptual understanding. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Andrade-Lotero EJ, Ortiz-Duque JM, Velasco-García JA, Goldstone RL.   +3 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Editorial: Broadening our conceptual understanding of endogenous opioids in systems neuroscience. [PDF]

Front Syst Neurosci, 2023
Tejeda HA, Massaly N, Corder G, Cahill CM.   +3 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Enhancing Students' Conceptual Understanding of Newton Law with Conceptual Problem Solving Learning: An Experimental Study

International Journal of Education and Teaching Zone
This study aims to examine the effectiveness of Conceptual Problem Solving-based learning in improving student conceptual understanding of Newtonian mechanics.
Tsania Nur Diyana, Sutopo Sutopo
doaj   +1 more source

Conceptual understanding in science learning and the role of four psychometric variables: a person-centered approach. [PDF]

Front Psychol, 2023
Vaiopoulou J, Tsikalas T, Stamovlasis D, Papageorgiou G.   +3 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source