Results 161 to 170 of about 2,211,033 (313)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Correction: Identifying barriers to lipoprotein(a) testing in secondary cardiovascular prevention and co-designing implementation strategies: an Italian behavior change wheel-informed study. [PDF]

Front Cardiovasc Med
Arca M, Marcucci R, Maggioni AP, Bilato C, Stabile E, Cipollone F, Capodanno D, Liuzzo G, Varbella F, Guerra F, Carugo S, Valsecchi D, Cangini M, Ghiringhelli AM, Parretti S, Donnaloja F, Catapano AL.   +16 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The CSF-Inventory: A Self-Reported Assessment Tool for Spinal Cerebrospinal Fluid (CSF) Leak Symptoms and Functional Impact. [PDF]

Eur J Neurol
Wolf K, El Rahal A, Fung C, Peters M, Lützen N, Piechowiak EI, Dobrocky T, Overstijns M, Otte M, Moeller C, Zander C, da Silva VV, Urbach H, Beck J, Volz F.   +14 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Conceptual HyperGraph and Conceptual SuperHyperGraph

Abstract. A finite hypergraph generalizes an ordinary graph by permitting a hyperedge to connect anynonempty subset of vertices, thereby capturing multiway interactions. Extending this idea, a finite SuperHyperGraph is obtained by iterating the powerset operation, producing nested families of vertex and edgesets that model multi-layer relational ...
openaire   +2 more sources

Using a Programme-Level Approach to Developing Reflective Practice in Health Professions Education in the Age of AI. [PDF]

Clin Teach
Sapsed C, Palermo C, D'Souza I, Spencer-Smith M, Cowley A, Davidson Z, McCartan J, Paynter S, Pereira I, Robinson L, Susigan D, Svikers A.   +11 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Early Recurrence Patterns After Neoadjuvant Chemoradiotherapy and Chemoimmunotherapy in Oesophageal Squamous Cell Carcinoma: A Multicentre Study. [PDF]

Eur J Cardiothorac Surg
Sun C, Chen C, Sun H, Liu H, Chen Q, Wang Z, Chen J, Cho WC, Li Z, Liu Z, Ma D, Ye M, Wang C, Wang Q, Leng X, Han Y, Wang Q, Lv J, Chen H, Zhao J, Yan X, Lv H, Tian Z, Wang C, Xu L, Jiang Y, Zhang Z, Zhong Q, Lin J, Mei X, Li X, Qian D, Zhu C, Guo X, Shen J.   +34 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source