Results 151 to 160 of about 2,211,033 (313)

Conceptual engineering and conceptual innovation

Inquiry
Conceptual engineering, motivated one natural way, involves the search for new concepts. But to what extent does conceptual engineering as practiced involve such conceptual innovation, and to what extent can it do so? In this paper, I first argue that conceptual engineering as practiced surprisingly does not appear to involve conceptual innovation, and
openaire   +2 more sources

Inference, Language, and Situated Conceptualization

The purpose of this writing is to exercise a philosophical lesson about the role of linguistic inference in cognitive science accounts of conceptualization. I argue that while it makes good sense to endorse the idea that our conceptual scheme comes about
Porto, Alexander
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Conceptual Infrastructure and Conceptual Engineering

, 2023
Jochen Briesen, Steffen Koch
openaire   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Inpatient Complications and Outcomes for Burn Patients Admitted with Opioid-Positive Drug Screens. [PDF]

J Burn Care Res
Swafford EP, Fijany AJ, Murphy TJ, Vyas P, Garcia JT, Ballou J, Beyene RT, Gondek S, Wagner A, Slater ED.   +9 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Global disparities in the availability and reimbursement of systemic therapies for renal cell carcinoma: results of the International ARON-AID Survey. [PDF]

Oncologist
Urun Y, Sridharan K, Zgura A, Zayed A, Laguado MIZ, Yetisyigit T, Yano A, Wenzel M, Vau N, Tural D, Trindade K, Tran B, Ting FIL, Templeton AJ, Takeshita H, Sunela K, Souza VC, Sooro MA, Soares A, Siva S, Singh A, Silveira G, Shah S, Seront E, Schutz FA, Schurmann MLV, Schieber T, Scagliarini S, Sargsyan A, Simonetti CS, Rushanyan M, Roviello G, Rodriguez-Vida A, Rodriguez Gonzalez OE, Roberts R, Van der Veldt AAM, Rizzo M, Rizzo A, Poprach A, Pirshtuk A, Pinto A, Pierce E, Peñaloza JM, Pedrani M, Park SH, Okunade IA, Odounga KF, Noriega J, Noorzai E, Coronel MTN, Navratil J, Myint ZW, Mutavdzic V, Mukuku O, Mugarura R, Marques Monteiro FS, Mohamed AH, Mmereki D, Messina C, Melichar B, Mukaz Mbey P, Maturana E, Matthews D, Massari F, Martínez E, Maitre P, Maison P, Ndjembidouma BCM, Lu K, Li J, Li H, de Moura Leite L, Lalani AA, Küronya Z, Kucharz J, Koumba AB, Kopp RM, Kopecky J, Kihn-Alarcón AJ, Keskin Ö, Kabdullina K, Juarez Á, Fita MJJ, Jardim DL, James LG, Grande E, De Liaño AG, Giannatempo P, Ghosn M, Gauna C, Quiroga MNG, Fujita K, Pereira Freitas MR, Fiala O, Lazzaro MF, Pacheco GMF, Esan TO, Esan DT, Du Plessis D, Delgado SN, Crabb SJ, Cano RC, Corrales L, Chen J, Cayol F, Silva CC, Carneiro APCD, Caprinciu GA, Campos S, Büttner T, Buti S, Bukhari N, Buchler T, Bourlon MT, Bolek H, Boegemann M, Bilen MA, Vaca LB, Bastos DA, Barthelemy P, Bardakhchyan S, Barbu MA, Baranseh J, Bamias A, Bakenga A, Anguera G, Angel M, Silva CAC, Alonso-Gordoa T, Almugbel F, Almufti R, Almeida TL, Aliyev A, Aliaga C, Aleem U, Akkus E, Aceituno LG, Abidi SH, Abahssain H, Tartari F, Molina-Cerrillo J, Santoni M.   +141 more
europepmc   +1 more source